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A neuroimaging biomarker for sustained experimental and clinical pain
펼치기 Authors and Affiliations
Abstract

Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients. In this study, we developed a functional magnetic resonance imaging signature based on whole-brain functional connectivity that tracks experimentally induced tonic pain intensity and tested its sensitivity, specificity and generalizability to clinical pain across six studies (total n = 334). The signature displayed high sensitivity and specificity to tonic pain across three independent studies of orofacial tonic pain and aversive taste. It also predicted clinical pain severity and classified patients versus controls in two independent studies of clinical low back pain. Tonic and clinical pain showed similar network-level representations, particularly in somatomotor, frontoparietal and dorsal attention networks. These patterns were distinct from representations of experimental phasic pain. This study identified a brain biomarker for sustained pain with high potential for clinical translation.

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논문정보   
- 형식: Research article
- 게재일: 2021년 01월 (BRIC 등록일 2021-01-05)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Neuroscience, Medicine, Physiology
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