Selected Publications

Jungeun An, Anjana Rao, Myunggon Ko (2017)
TET family dioxygenases and DNA demethylation in stem cells and cancers.
Exp. Mol. Med., 49(4):e323

Nair VS, Song MH, Ko M, Oh KI (2016)
DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases.
Mol. Cells, 39(12):888-897

Xiaotian Zhang*, Jianzhong Su*, Mira Jeong*, Myunggon Ko, Yun Huang, Hyun Jung Park, Anna Guzman, Yong Lei, Yung-Hsin Huang, Anjana Rao, Wei Li & Margaret A Goodell (2016)
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Nat. Genet., 48(9):1014-23

Sara Motagner, Cristina Leoni, Stefan Emming, Giulia Della Chiara, Chiara Balestrieri, Iros Barozzi, Viviana Piccol, Susan Tougher, Myunggon Ko, Anjana Rao, Cioacchino Natoli, Silvia Monticelli (2016)
TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities.
Cell Reports, 15:1566-1579

Jungeun An, Edahi Gonzalez-Avalos, Ashu Chawla, Mira Jeong, Isaac F. Lopez-Moyado, Wei Li, Margaret A. Goodell, Lukas Chavez*, Myunggon Ko*, Anjana Rao* (2015)
Acute loss of TET function results in aggressive myeloid cancer in mice.
Nat. Comm., 6:10071 (*co-corresponding authors)

Myunggon Ko#, Jungeun An, Anjana Rao (2015)
DNA methylation and hydroxymethylation in hematologic differentiation and transformation.
Curr. Opin. Cell Biol., 37: 91-101 (#corresponding author)

Jae-A Han, Jungeun An, Myunggon Ko (2015)
Functions of TET proteins in hematopoietic transformation.
Mol. Cells, 38:925-935

Evisa Gjini, Marc R. Mansour, Jeffry D. Sander, Nadine Moritz, Ashley T. Nguyen, Michiel Kesarsing, Si Chen, Myunggon Ko, You-Yi Kuang, Song Yang, Yi Zhou, Leonard I. Zon, J. Keith Joung, Anjana Rao, A. Thomas Look (2015)
A zebrafish model of myelodysplasia produced through tet2 genomic editing.
Mol. Cell. Biol., 35:789-804

Myunggon Ko*, Jungeun An*, William A. Pastor, Sergei Koralov, Klaus Rajewsky, Anjana Rao (2015)
TET proteins and 5-methylcytosine oxidation in hematological cancers.
Immunological Reviews, 263:6-21 (*equally contributed)

Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Ko M, Wang H, Chen R, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W and Goodell MA (2014)
Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a.
Nat. Genet., 46:17-23

Myunggon Ko*, Jungeun An*, Hozefa S. Bandukwala, Lukas Chavez, Tarmo Aijo, William A. Pastor, Matthew F. Segal, Huiming Li, Kian Peng Koh, Harri Lahdesmaki, Patrick G. Hogan, L. Aravind, Anjana Rao (2013)
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.
Nature, 497:122-126

Masato Sasaki, Christiane B. Knobbe, Momoe Itsumi, Andrew J. Elia, Isaac S. Harris, Iok In Christine Chio, Rob A. Cairns, Susan McCracken, Andrew Wakeham, Jillian Haight, Annick You Ten, Bryan Snow, Takeshi Ueda, Satoshi Inoue, Kazuo Yamamoto, Myunggon Ko, Anjana Rao, Katharine E. Yen, Shinsan M. Su, and Tak Wah Mak (2012)
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Genes Dev., 26:2038-2049

Jinwook Choi*, Myunggon Ko* Shin Jeon, Yoon Jeon, Kyungsoo Park, Changjin Lee, Ho Lee, and Rho H (2012)
The SWI/SNF-like BAF complex is essential for early B cell development.
J. Immunol., 188:3791-3803

Myunggon Koand Anjana Rao (2011)
TET2: epigenetic safeguard for HSC.
Blood, 118:4501-4503

Myunggon Ko*, Hozefa S. Bandukwala*, Jungeun An, Edward D. Lamperti, Elizabeth C. Thompson, Ryan Hastie, Angeliki Tsangaratou, Klaus Rajewsky, Sergei B. Koralov, and Anjana Rao (2011)
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice.
Proc. Natl. Acad. Sci. USA, 108:14566-14571

William A. Pastor*, Utz J. Pape*, Yun Huang*, Hope R. Henderson, Ryan Lister, Myunggon Ko, Erin M. McLoughlin, Yevgeny Brudno, Sahasransu Mahapatra, Philipp Kapranov, Mamta Tahiliani, George Q. Daley, X. Shirley Liu, Joseph R. Ecker, Patrice M. Milos, Suneet Agarwal & Anjana Rao (2011)
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.
Nature, 473:394-397

Jeongeun Ahn*, Myunggon Ko*, Changjin Lee, Jieun Kim, Hana Yoon, and Rho H.Seong (2011)
Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulatingp21WAF1/CIP1expression.
Oncogene, 30:445-456

Myunggon Ko*, Yun Huang*, Anna M. Jankowska, Utz J. Pape, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, Rebecca Ganetzky, X. Shirley Liu, L. Aravind, Suneet Agarwal, Jaroslaw P. Maciejewski& Anjana Rao (2010)
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.
Nature, 468:839-843