BioWave  Vol. 20 No. 11
경희대학교 유전체학 연구실 김광우 교수
연구실 홈페이지
실험실 소개  
Our research has the overall theme of understanding genomic variants associated with common complex autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus by using a tremendous amount of genomic, transcriptomic and epigenetic data from cutting edge technologies like microarray and next-generation sequencing.

lab_intro1

연구분야  
Kim Lab pursues four distinct goals of research:
1. Identifying causal genetic variants that confer risk of diseases
2. Understanding underlying biological mechanisms implicated by disease variants
3. Developing prediction model that explains risk of immune disease or drug response in individuals
4. Understanding interaction between disease causes

Currently active research projects
보건복지부 세계선도 의과학자 육성사업 (HI15C3182)
연구재단 전략과제 (2017R1E1A1A01076388)
연구성과  
Selected Publications(¶: first authors; *: corresponding authors)

  • Kwangwoo Kim¶* (2018)
    Massive false positive gene-gene interactions by Rothman’s additive model.
    Ann. Rheum. Dis., doi: 10.1136/annrheumdis-2018-214297


  • Young Bin Joo¶, Jiwoo Lim, Betty P. Tsao, Swapan K. Nath, Kwangwoo Kim*, Sang-Cheol Bae* (2018)
    Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort.
    Sci. Rep., 8:9962


  • Kwangwoo Kim¶, So-Young Bang, Hye-Soon Lee, and Sang-Cheol Bae* (2017)
    Update on the genetic architecture of rheumatoid arthritis.
    Nat. Rev. Rheumatol., 13:13-24


  • Christopher J. Lessard¶, Satria Sajuthi¶, Jian Zhao¶, Kwangwoo Kim¶, John A. Ice, He Li, Hannah Ainsworth, Astrid Rasmussen, Jennifer A. Kelly, Mindy Marion, So-Young Bang, Young Bin Joo, Jeongim Choi, Hye-Soon Lee, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Soo-Kon Lee, Jung-Yoon Choe, Seung Cheol Shim, Ji Hee Oh, Young Jin Kim, Bok Ghee Han, Nan Shen, Hwee Siew Howe, Edward K. Wakeland, QuanZhen Li, Yeong Wook Song, Patrick M. Gaffney, Marta E. Alarcon-Riquelme, Lindsey A. Criswell, Chaim O. Jacob, Robert P. Kimberly, Timothy J. Vyse, John B. Harley, Kathy L. Sivils, Sang-Cheol Bae*, Carl D. Langefeld, and Betty P. Tsao* (2016)
    Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
    Arthritis Rheumatol., 68(5):1197-209


  • Celi Sun¶, Julio E. Molineros¶, Loren L. Looger¶, Xu-jie Zhou¶, Kwangwoo Kim¶, Yukinori Okada, Jianyang Ma, Yuan-yuan Qi, Xana Kim-Howard, Prasenjeet Motghare, Krishna Bhattarai, Adam Adler, So-Young Bang, Hye-Soon Lee, Tae-Hwan Kim, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Yong-Beom Park, Jung-Yoon Choe, Seung Cheol Shim, Yuta Kochi, Akari Suzuki, Michiaki Kubo, Takayuki Sumida, Kazuhiko Yamamoto, Shin-Seok Lee, Young Jin Kim, Bok-Ghee Han, Mikhail Dozmorov, Kenneth M. Kaufman, Jonathan D. Wren, John B. Harley, Nan Shen, Kek Heng Chua, Hong Zhang, Sang-Cheol Bae*, and Swapan K. Nath* (2016)
    High-density genotyping of immune-related loci and follow-up genetic association identify ten novel SLE susceptibility genes in individuals with Asian ancestry.
    Nat. Genet., 48(3):323-30


  • Kwangwoo Kim¶, Xia Jiang¶, Jing Cui¶, Bing Lu, Karen H. Costenbader, Jeffrey A. Sparks, So-Young Bang, Hye-soon Lee, Yukinori Okada, Soumya Raychaudhuri, Lars Alfredsson, Sang-Cheol Bae*, Lars Klareskog*, and Elizabeth W. Karlson* (2015)
    Interactions between amino-acid-defined MHC class II variants and smoking for seropositive rheumatoid arthritis.
    Arthritis Rheumatol., 67(10):2611-23


  • Kwangwoo Kim¶, So-Young Bang, Hye-Soon Lee, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Young Mo Kang, Seong-Kyu Kim, NChang-Hee Suh, Seung-Cheol Shim, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Jung-Yoon Choe, Hyoung Doo Shin, Jong-Young Lee, Bok-Ghee Han, Swapan K. Nath, Steve Eyre, John Bowes, Dimitrios A. Pappas, Joel M. Kremer, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Arlestig, Yukinori Okada, Dorothee Diogo, Katherine P. Liao, Elizabeth W. Karlson, Soumya Raychaudhuri, Solbritt Rantapaa-Dahlqvist, Javier Martin, Lars Klareskog, Leonid Padyukov, Peter K. Gregersen, Jane Worthington, Jeffrey D. Greenberg, Robert M. Plenge*, and Sang-Cheol Bae* (2015)
    High-Density Genotyping of Immune Loci in Koreans and Europeans Identifies 8 New Rheumatoid Arthritis Risk Loci.
    Ann. Rheum. Dis., 74(3):e13


  • Kwangwoo Kim¶, So-Young Bang, Hye-Soon Lee, Yukinori Okada, Buhm Han, Woei-Yuh Saw, Yik-Ying Teo, and Sang-Cheol Bae* (2014)
    The HLA-DRβ1 Amino Acid Positions 11-13-26 Explain the Majority of SLE-MHC Associations.
    Nat. Commun., 5:5902


  • Kwangwoo Kim¶, Elizabeth E. Brown¶, Chan-Bum Choi, Marta E. Alarcon-Riquelme on behalf of BIOLUPUS, Jennifer A. Kelly, Stuart B. Glenn, Joshua O. Ojwang, Adam Adler, Hye-Soon Lee, Susan A. Boackle, Lindsey A. Criswell, Graciela S. Alarcon, Jeffrey C. Edberg, Anne M. Stevens, Chaim O. Jacob, Gary S. Gilkeson, Diane L. Kamen, Betty P. Tsao, Juan-Manuel Anaya, Joel M. Guthridge, Swapan K. Nath, Bruce Richardson, Amr H. Sawalha, Young Mo Kang, Seung Cheol Shim, Chang-Hee Suh, Soo-Kon Lee, Chang-sik Kim, Joan T. Merrill, Michelle Petri, Rosalind Ramsey-Goldman, Luis M. Vila, Timothy B. Niewold, Javier Martin, Bernardo A. Pons-Estel on behalf of GENLES, Timothy J. Vyse, Barry I. Freedman, Kathy L. Moser, Patrick M. Gaffney, Adrienne Williams, Mary Comeau, John D. Reveille, Judith A. James, R. Hal Scofield, Carl D. Langefeld, Kenneth M. Kaufman, John B. Harley, Changwon Kang*, Robert P. Kimberly*, and Sang-Cheol Bae* (2012)
    Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.
    Ann. Rheum. Dis., 71(11):1809-1814


  • Kwangwoo Kim¶, So-Yeon Park¶, Taehyeung Kim, Young Mo Kang, Seung-Cheol Shim, Chang-Hee Suh, Yong-Beom Park, Chang-sik Kim, Changwon Kang*, and Sang-Cheol Bae* (2011)
    Replicated Association of a Regulatory Polymorphism in the Interferon-gamma Gene with Lupus Susceptibility.
    Ann. Rheum. Dis., 70(10):1878-1879


  • Kwangwoo Kim¶, Soo-Kyung Cho¶, Andrea Sestak, Bahram Namjou, Changwon Kang*, and Sang-Cheol Bae* (2010)
    Interferon-gamma Gene Polymorphisms Associated with Susceptibility to Systemic Lupus Erythematosus.
    Ann. Rheum. Dis.,69(6):1247-1250
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