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Nanoparticle‐based nucleic acid conjugates (NP‐NACs) hold great promise for theragnostic applications. However, several limitations have hindered the realization of their full potential in the clinical treatment of cancer and other diseases. In diagnoses, NP‐NACs suffer from low signal‐to‐noise ratios, while the efficiency of NP‐NACs‐mediated cancer therapies has been limited by the adaptation of alternative prosurvival pathways in cancer cells. The recent emergence of personalized and precision medicine has outlined the importance of having both accurate diagnosis and efficient therapeutics in a single platform. As such, the controlled assembly of hybrid graphene oxide/gold nanoparticle (Au@GO NP)‐based cancer‐specific NACs (Au@GO NP‐NACs) for multimodal imaging and combined therapeutics is reported. The developed Au@GO NP‐NACs show excellent surface‐enhanced Raman scattering (SERS)‐mediated live‐cell cancer detection and multimodal synergistic cancer therapy through the use of photothermal, genetic, and chemotherapeutic strategies. Synergistic and selective killing of cancer cells are then demonstrated using in vitro microfluidic models. Moreover, with the distinctive advantages of the Au@GO NP‐NACs for cancer theragnostics, precision cancer treatment through the detection of cancer cells in vivo using SERS followed by efficient ablation of tumors is shown. Therefore, the Au@GO NP‐NACs can pave a new road for advanced disease theragnostics.
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학술웨비나 - 연구성과
High-amplitude cofluctuation의 대뇌 functional connectivity에서의 역할 [Proc. Natl. Acad. Sci. USA]
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개최일시 : 1월 18일 (월) 오전 10시 (한국시간)
발표연사 : 조영흔 (Indiana University)
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학술웨비나 - 연구성과
H3K27M을 지닌 소아뇌종양에서 신진대사와 후성유전학의 관계 [Cancer Cell]
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개최일시 : 2월 4일 (목) 오전 11시 (한국시간)
발표연사 : 정찬 (University of Michigan)
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학술웨비나 - 연구성과
약물유전단백체학을 활용한 교모세포종 (Glioblastoma) 연구 [Nat. Commun.]
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개최일시 : 2월 16일 (화) 오후 02시 (한국시간)
발표연사 : 오세진 (연세대학교 의과대학)
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학술웨비나 - 연구성과
스무색 만으로 완성하지 못하는 단백질 디자인 [Nat. Commun.]
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개최일시 : 2월 17일 (수) 오전 10시 (한국시간)
발표연사 : 이준구 (Northwestern University)
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