KAIST, 기초과학연구원


Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways
펼치기 Authors and Affiliations

To obtain insights into striatal neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatal neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatal neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, value-related spatial clusters were progressively refined during classical conditioning. Our study shows the broad and learning-dependent spatial organization of functional clusters of dorsal striatal neurons in the direct and indirect pathways. These findings further argue against the classic model of the basal ganglia and support the importance of spatiotemporal patterns of striatal neuronal ensemble activity in the control of behavior.

striatum, calcium imaging, probabilistic classical conditioning, valuereward

- 형식: Research article
- 게재일: 2020년 10월 (BRIC 등록일 2020-10-15)
- 연구진: 국내연구진태극기
- 분야: Neuroscience
댓글 (0)
웨비나 참석자 모집중...
HOME   |   이용약관   |   개인정보처리방침