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Reviews & Commentaries
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
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Abstract

DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole genome, including repetitive sequences, enhancers, promoters, and gene bodies. Interestingly, however, non-CpG methylation is restricted to specific cell types, such as pluripotent stem cells, oocytes, neurons, and glial cells. Thus, accumulation of methylation at non-CpG sites and CpG sites in neurons seems to be involved in development and disease etiology. Here, we provide an overview of CpG and non-CpG methylation and their roles in neurological diseases. View Full-Text

Keywords:   epigenetics; CpG methylation; non-CpG methylation

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논문정보   
- 형식: Review Paper
- 게재일: 2017년 05월 (BRIC 등록일 2019-12-24)
- 연구진: 국내연구진태극기
- 분야: Genetics
- 피인용횟수: 최근 3년간 60회 이상 인용된 논문
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