이은주 (Eun Ju Lee) 서울대학교
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Food Chem., Volume 120, Issue 1, 1 May 2010, Pages 134-139 | https://doi.org/10.1016/j.foodchem.2009.09.088
Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities
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Abstract

Thirteen phenolic constituents, luteolin (1), protocatechuic acid (2), caffeic acid (3), flavoyadorinin-B (4), 4,5-dicaffeoylquinic acid (5), luteolin 7-O-β-d-glucopyranoside (7), 3,5-dicaffeoylquinic acid methyl ester (8), methyl chlorogenate (9), quercetin 3-O-β-d-glucopyranoside (10), 3,5-dicaffeoylquinic acid (11), rhoifolin (12), chlorogenic acid (13), and a novel phenolic glucoside benzoate, vanillic acid 4-O-β-d-(6-O-benzoylglucopyranoside) (6), were isolated from the flower buds of Lonicera japonica. Flavoyadorinin-B (4) was isolated for the first time from a Caprifoliaceae plant. The structures of 1–13 were determined on the basis of chemical and spectroscopic evidence. These compounds were screened for their 5-lipoxygenase inhibitory activity. Only luteolin (1) showed significant inhibitory activity against 5-LOX-catalysed leukotriene production.

Keywords : Lonicera japonica; Phenolics; Vanillic acid 4-O-β-d, -(6-O-benzoylglucopyranoside); 5-Lipoxygenase (5-LOX)

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피인용횟수 120회 이상
등록일 2019.11.26
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