서울대학교
Phenolic constituents from the flower buds of Lonicera japonica and their 5-lipoxygenase inhibitory activities
펼치기 Authors and Affiliations
Abstract

Thirteen phenolic constituents, luteolin (1), protocatechuic acid (2), caffeic acid (3), flavoyadorinin-B (4), 4,5-dicaffeoylquinic acid (5), luteolin 7-O-β-d-glucopyranoside (7), 3,5-dicaffeoylquinic acid methyl ester (8), methyl chlorogenate (9), quercetin 3-O-β-d-glucopyranoside (10), 3,5-dicaffeoylquinic acid (11), rhoifolin (12), chlorogenic acid (13), and a novel phenolic glucoside benzoate, vanillic acid 4-O-β-d-(6-O-benzoylglucopyranoside) (6), were isolated from the flower buds of Lonicera japonica. Flavoyadorinin-B (4) was isolated for the first time from a Caprifoliaceae plant. The structures of 1–13 were determined on the basis of chemical and spectroscopic evidence. These compounds were screened for their 5-lipoxygenase inhibitory activity. Only luteolin (1) showed significant inhibitory activity against 5-LOX-catalysed leukotriene production.

Keywords : Lonicera japonica; Phenolics; Vanillic acid 4-O-β-d, -(6-O-benzoylglucopyranoside); 5-Lipoxygenase (5-LOX)

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논문정보   
- 형식: Research article
- 게재일: 2010년 05월 (BRIC 등록일 2019-11-26)
- 연구진: 국내연구진태극기
- 피인용횟수: 120회 이상 인용된 논문
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