아주대학교 의과대학, University of Tennessee

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Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells
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Abstract

Plasma is generated by ionizing neutral gas molecules, resulting in a mixture of energy particles, including electrons and ions. Recent progress in the understanding of non-thermal atmospheric plasma has led to applications in biomedicine. However, the exact molecular mechanisms involved in plasma-induced cell growth arrest are unclear. In this study, we investigated the feasibility of non-thermal atmospheric plasma treatment for cancer therapy and examined the mechanism by which plasma induces anti-proliferative properties and cell death in human colorectal cancer cells. Non-thermal atmospheric plasma induced cell growth arrest and induced apoptosis. In addition, plasma reduced cell migration and invasion activities. As a result, we found that plasma treatment to the cells increases β-catenin phosphorylation, suggesting that β-catenin degradation plays a role at least in part in plasma-induced anti-proliferative activity. Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function.

Keywords : Non-thermal atmospheric plasma; Apoptosis; Colorectal cancer; Growth arrest; β-Catenin

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논문정보   
- 형식: Research article
- 게재일: 2010년 12월 (BRIC 등록일 2019-11-22)
- 연구진: 국내+국외 연구진
- 분야: Biotechnology
- 피인용횟수: 120회 이상 인용된 논문
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