백승준 (Seung Joon Baek) University of Tennessee
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J. Biotechnol., Volume 150, Issue 4, December 2010, Pages 530-538 | https://doi.org/10.1016/j.jbiotec.2010.10.003
Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells
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Abstract

Plasma is generated by ionizing neutral gas molecules, resulting in a mixture of energy particles, including electrons and ions. Recent progress in the understanding of non-thermal atmospheric plasma has led to applications in biomedicine. However, the exact molecular mechanisms involved in plasma-induced cell growth arrest are unclear. In this study, we investigated the feasibility of non-thermal atmospheric plasma treatment for cancer therapy and examined the mechanism by which plasma induces anti-proliferative properties and cell death in human colorectal cancer cells. Non-thermal atmospheric plasma induced cell growth arrest and induced apoptosis. In addition, plasma reduced cell migration and invasion activities. As a result, we found that plasma treatment to the cells increases β-catenin phosphorylation, suggesting that β-catenin degradation plays a role at least in part in plasma-induced anti-proliferative activity. Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function.

Keywords : Non-thermal atmospheric plasma; Apoptosis; Colorectal cancer; Growth arrest; β-Catenin

Category: Biotechnology
피인용횟수 120회 이상
등록일 2019.11.22
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