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Clofazimine-Containing Regimen for the Treatment of Mycobacterium abscessus Lung Disease
펼치기 Authors and Affiliations
Abstract

Patients with lung disease caused by Mycobacterium abscessus subsp. abscessus (here M. abscessus) typically have poor treatment outcomes. Although clofazimine (CFZ) has been increasingly used in the treatment of M. abscessus lung disease in clinical practice, there are no reported data on its effectiveness for this disease. This study sought to evaluate the clinical efficacy of a CFZ-containing regimen for the treatment of M. abscessus lung disease. We performed a retrospective review of the medical records of 42 patients with M. abscessus lung disease who were treated with CFZ-containing regimens between November 2013 and January 2015. CFZ was administered in combination with other antibiotics as an initial antibiotic regimen in 15 (36%) patients (initial treatment group), and it was added to an existing antibiotic regimen for refractory M. abscessus lung disease in 27 (64%) patients (salvage treatment group). Overall, there was an 81% treatment response rate based on symptoms and a 31% response rate based on radiographic findings. Conversion to culture-negative sputum samples was achieved in 10 (24%) patients after CFZ-containing antibiotic treatment, and during treatment, there were significant decreases in the positivity of semiquantitative sputum cultures for acid-fast bacilli in both the initial (P = 0.018) and salvage (P = 0.001) treatment groups. Our study suggests that CFZ-containing regimens may improve treatment outcomes in patients with M. abscessus lung disease and that a prospective evaluation of CFZ in M. abscessus lung disease is warranted.

KEYWORDS : nontuberculous mycobacteria, Mycobacterium abscessus, clofazimine, treatment outcome

주소복사
논문정보   F1000선정
- 형식: Research article
- 게재일: 2017년 06월 (BRIC 등록일 2019-09-26)
- 연구진: 국내(교신)+국외 연구진태극기
- 추천: Faculty of 1000 Biology
- 추천사유: Skerrett S: F1000Prime Recommendation of [Yang B et al., Antimicrob Agents Chemother 2017 61(6)]. In F1000Prime, 25 Sep 2019; 10.3410/f.727459148.793565564
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