고원중 (Won-Jung Koh) 삼성서울병원, 성균관대학교 의과대학
이메일
Antimicrob. Agents Chemother., June 2017, Volume 61 Issue 6, e02052-16 | DOI: 10.1128/AAC.02052-16
Clofazimine-Containing Regimen for the Treatment of Mycobacterium abscessus Lung Disease
펼치기 Authors and Affiliations
Abstract

Patients with lung disease caused by Mycobacterium abscessus subsp. abscessus (here M. abscessus) typically have poor treatment outcomes. Although clofazimine (CFZ) has been increasingly used in the treatment of M. abscessus lung disease in clinical practice, there are no reported data on its effectiveness for this disease. This study sought to evaluate the clinical efficacy of a CFZ-containing regimen for the treatment of M. abscessus lung disease. We performed a retrospective review of the medical records of 42 patients with M. abscessus lung disease who were treated with CFZ-containing regimens between November 2013 and January 2015. CFZ was administered in combination with other antibiotics as an initial antibiotic regimen in 15 (36%) patients (initial treatment group), and it was added to an existing antibiotic regimen for refractory M. abscessus lung disease in 27 (64%) patients (salvage treatment group). Overall, there was an 81% treatment response rate based on symptoms and a 31% response rate based on radiographic findings. Conversion to culture-negative sputum samples was achieved in 10 (24%) patients after CFZ-containing antibiotic treatment, and during treatment, there were significant decreases in the positivity of semiquantitative sputum cultures for acid-fast bacilli in both the initial (P = 0.018) and salvage (P = 0.001) treatment groups. Our study suggests that CFZ-containing regimens may improve treatment outcomes in patients with M. abscessus lung disease and that a prospective evaluation of CFZ in M. abscessus lung disease is warranted.

KEYWORDS : nontuberculous mycobacteria, Mycobacterium abscessus, clofazimine, treatment outcome

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추천자 : Faculty of 1000 Biology
Skerrett S: F1000Prime Recommendation of [Yang B et al., Antimicrob Agents Chemother 2017 61(6)]. In F1000Prime, 25 Sep 2019; 10.3410/f.727459148.793565564
등록일 2019.09.26
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