경희대학교, Rutgers, The State University of New Jersey

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A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
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Abstract
Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Addressing these hurdles, scientists have designed bioscaffolds that mimic the natural tissue microenvironment to deliver physical and soluble cues. However, several significant obstacles including burst release of drugs, insufficient cellular adhesion support, and slow scaffold degradation rate remain to be overcome before the full potential of bioscaffold?based stem-cell therapies can be realized. To this end, we developed a biodegradable nanoscaffold-based method for enhanced stem cell transplantation, differentiation, and drug delivery. These findings collectively support the therapeutic potential of our biodegradable hybrid inorganic (BHI) nanoscaffolds for advanced stem cell transplantation and neural tissue engineering.
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논문정보   
- 형식: Research article
- 게재일: 2018년 08월 (BRIC 등록일 2018-08-09)
- 연구진: 국내(교신)+국외 연구진태극기
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