University of Illinois at Urbana-Champaign


Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

Gunchul Shin,1,17 Adrian M. Gomez,2,17 Ream Al-Hasani,2,17 Yu Ra Jeong,3,17 Jeonghyun Kim,1,17 Zhaoqian Xie,4,5,17 Anthony Banks,1 Seung Min Lee,1 Sang Youn Han,1,6 Chul Jong Yoo,7 Jong-Lam Lee,7 Seung Hee Lee,7 Jonas Kurniawan,1 Jacob Tureb,1 Zhongzhu Guo,1 Jangyeol Yoon,1 Sung-Il Park,8 Sang Yun Bang,9 Yoonho Nam,1 Marie C. Walicki,2 Vijay K. Samineni,2,10 Aaron D. Mickle,2,10 Kunhyuk Lee,1 Seung Yun Heo,1 Jordan G. McCall,2,10 Taisong Pan,11 Liang Wang,12 Xue Feng,5 Tae-il Kim,13 Jong Kyu Kim,6 Yuhang Li,14 Yonggang Huang,4 Robert W. Gereau IV,2,10,15,16 Jeong Sook Ha,3,* Michael R. Bruchas,2,10,15,16,18,* and John A. Rogers1,*

1Department of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA
2Division of Basic Research, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA
3Department of Chemical and Biological Engineering and KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Republic of Korea
4Departments of Civil and Environmental Engineering, Mechanical Engineering, and Materials Science and Engineering, Center for Engineering and Health and Skin Disease Research Center, Northwestern University, Evanston, IL 60208, USA
5AML, Department of Engineering Mathematics, Center for Mechanics and Materials, Tsinghua University, Beijing 100084, China
6Display Research Center, Samsung Display Co., Yongin, Gyeonggi-do 446-920, Republic of Korea
7Department of Materials Science and Engineering, Pohang University of Science & Technology Pohang, Gyeongbuk 790-784, Republic of Korea
8Department of Electrical Engineering, Texas A&M University, College Station, TX 77843, USA
9Department of Electrical and Computer Engineering, New York University, Brooklyn, NY 11201, USA
10Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA
11State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, People’s Republic of China
12Institute of Chemical Machinery and Process Equipment, Zhejiang University, Hangzhou 310027, People’s Republic of China
13School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic of Korea
14Institute of Solid Mechanics, Beihang University, Beijing 100191, China
15Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA
16Department of Biomedical Engineering, Washington University, St. Louis, MO 63110, USA
17Co-first author
18Lead Contact

*Correspondence: Jeong Sook Ha, Michael R. Bruchas, John A. Rogers

In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wireless options offer important capabilities that avoid some of these limitations, but the current size, bulk, weight, and wireless area of coverage is often disadvantageous. Here, we present a simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin, flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms. The devices combine subdermal magnetic coil antennas connected to microscale, injectable light-emitting diodes (LEDs), with the ability to operate at wavelengths ranging from UV to blue, green-yellow, and red. An external loop antenna allows robust, straightforward application in a multitude of behavioral apparatuses. The result is a readily mass-producible, user-friendly technology with broad potential for optogenetics applications.

Keywords : wireless, optogenetics, near-field communication, LED, VTA, NAc, ChR2, Chrimson, dopamine, reward

- 형식: Research article
- 게재일: 2017년 01월 (BRIC 등록일 2020-03-19)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Neuroscience
- 피인용횟수: 최근 3년간 60회 이상 인용된 논문
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