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Reviews & Commentaries
Excitation/inhibition Imbalance in Animal Models of ASDs

Eunee Lee1, a, Jiseok Leeb, 1, Eunjoon Kima, b, *

a Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 34141, Korea
b Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea

1 These authors contributed equally to this work.

*Correspondence to : Eunjoon Kim

Abstract
Imbalances between excitation and inhibition (E/I imbalance) in synaptic transmission and neural circuits have been implicated in autism spectrum disorders (ASDs). E/I imbalances are frequently observed in animal models of ASDs, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that E/I imbalance may contribute to the development and maintenance of ASDs and represent an important therapeutic target.

Key Words : excitation/inhibition balance; autism spectrum disorders; synapse; circuit; mouse models; psychiatric disorders

주소복사
논문정보   
- 형식: Review Paper
- 게재일: 2016년 05월 (BRIC 등록일 2020-03-19)
- 연구진: 국내연구진태극기
- 분야: Neuroscience
- 피인용횟수: 최근 3년간 60회 이상 인용된 논문
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