Tae-Hyung Kim1, Cheol-Heon Yea1,2, Sy-Tsong Dean Chueng1, Perry To-Tien Yin3, Brian Conley1, Kholud Dardir1, Yusin Pak4, Gun Young Jung4, Jeong-Woo Choi2,* and Ki-Bum Lee1,3,*
1 Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
2 Department of Chemical & Biomolecular Engineering, Sogang University, Seoul, Republic of Korea
3 Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
4 School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea
T.-H.K. and C.-H.Y. contributed equally to this work.
A novel cell-based biosensing platform is developed using a combination of sequential laser interference lithography and electrochemical deposition methods. This enables the sensitive discrimination of dopaminergic cells from other types of neural cells in a completely nondestructive manner. This platform and detection strategy may become an effective noninvasive in situ monitoring tool that can be used to determine stem cell fate for various regenerative applications.
Keywords : dopaminergic differentiation; electrochemical detection; large-scale nanopatterning; nanoelectrode arrays; neural stem cells