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Guiding Stem Cell Differentiation into Oligodendrocytes Using Graphene-Nanofiber Scaffold

Shreyas Shah1, Perry T. Yin2, Thiers M. Uehara3, Sy-Tsong Dean Chueng1, Letao Yang1 and Ki-Bum Lee1,2,*

1 Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
2 Department of Biomedical Engineering, Rutgers, State University of New Jersey, Piscataway, NJ, USA
3 Physics Institute of Sao Carlos, University of Sao Paulo, Sao Paulo, Brazil

*Corresponding Author : Ki-Bum Lee

Graphene-nanofiber hybrid scaffolds selectively guide the differentiation of neural stem cells into mature oligodendro­cytes, which are the myelinating cells of the central nervous system. Moreover, this process is facilitated without introducing differentiation inducers into the culture media, underscoring the potential of a biomaterials-approach for neural tissue engineering.

Keywords: biomaterials; electrospun nanofibers; graphene; neural stem cells; differentiation

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논문정보   
- 형식: Research article
- 게재일: 2014년 03월 (BRIC 등록일 2014-03-31)
- 연구진: 국외연구진
- 분야: Nanobio, Neuroscience, Cell_Biology
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