Guiding Stem Cell Differentiation into Oligodendrocytes Using Graphene-Nanofiber Scaffold
Shreyas Shah1, Perry T. Yin2, Thiers M. Uehara3, Sy-Tsong Dean Chueng1, Letao Yang1 and Ki-Bum Lee1,2,*
1 Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA
2 Department of Biomedical Engineering, Rutgers, State University of New Jersey, Piscataway, NJ, USA
3 Physics Institute of Sao Carlos, University of Sao Paulo, Sao Paulo, Brazil
*Corresponding Author : Ki-Bum Lee
Graphene-nanofiber hybrid scaffolds selectively guide the differentiation of neural stem cells into mature oligodendrocytes, which are the myelinating cells of the central nervous system. Moreover, this process is facilitated without introducing differentiation inducers into the culture media, underscoring the potential of a biomaterials-approach for neural tissue engineering.
Keywords: biomaterials; electrospun nanofibers; graphene; neural stem cells; differentiation