Northwestern University, 현 Rutgers, The State University of New Jersey

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Protein Nanostructures Formed via Direct-Write Dip-Pen Nanolithography

Ki-Bum Lee , Jung-Hyurk Lim , and Chad A. Mirkin *

Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208

*Corresponding author.

Abstract
We report a tip modification strategy coupled with dip-pen nanolithography for depositing proteins on a surface. This methodology offers patterning capabilities on the scale of 45 nm to many micrometers length. The biorecognition properties of nanofeatures composed of immunoglobulin-gamma (IgG) were confirmed by reacting the array with gold nanoparticles coated with anti-IgG. Furthermore, a two component nanoarray was fabricated in direct-write fashion by DPN, and the biorecognition properties of this structure were investigated by AFM without biodiagnostic labels.

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논문정보   
- 형식: Research article
- 게재일: 2003년 04월 (BRIC 등록일 2013-05-09)
- 연구진: 국외연구진
- 분야: Biochemistry
- 피인용횟수: 120회 이상 인용된 논문
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