Multimodal Magnetic Core–Shell Nanoparticles for Effective Stem-Cell Differentiation and Imaging
Birju Shah1, Perry T. Yin2, Shraboni Ghoshal1, Prof. Ki-Bum Lee1,*
1 Department of Chemistry & Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA)
2 Department of Biomedical Engineering, Rutgers, The State, University of New Jersey, Piscataway, NJ 08854 (USA)
*To whom correspondence may be addressed.
This work was financially supported by the NIH Director’s Innovator Award [(1DP20D006462-01), K.B.L.] and a N.J. Commission on Spinal Cord grant [(09-3085-SCR-E-0), K.B.L.]. P.T.Y. would like to acknowledge NIH Biotechnology Training Grant for support. We would like to thank Prasad Subramaniam and Nicholas Pasquale for their useful comments on the manuscript.
Special delivery! The title system, composed of a highly magnetic core surrounded by a thin uniform gold shell, has been synthesized and applied to the magnetically facilitated delivery of genetic material (siRNA or plasmid DNA) into neural stem cells (NSCs) for controlling their neural differentiation in a spatiotemporally controlled, biocompatible manner.
Keywords: magnetic properties; nanoparticles; neural stem cells; siRNA; stem cell differentiation