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Generation of a Library of Non-Toxic Quantum Dots for Cellular Imaging and siRNA Delivery

Prasad Subramaniam1, Seung Jae Lee1,2, Shreyas Shah1, Sahishnu Patel1, Valentin Starovoytov3, Ki-Bum Lee1,4,*

1Department of Chemistry and Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
2Center for Nano-Bio Fusion Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea
3Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
4School of Medicine, Kyung Hee University, Seoul, South Korea

*Corresponding author : Ki-Bum Lee
Department of Chemistry and Chemical Biology, Institute for Advanced Materials, Devices and Nanotechnology (IAMDN), Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

The development of non-toxic quantum dots and further investigation of their composition-dependent cytotoxicity in a high-throughput manner have been critical challenges for biomedical imaging and gene delivery. Herein, we report a rapid sonochemical synthetic methodology for generating a library of highly biocompatible ZnS-AgInS2 (ZAIS) quantum dots for cellular imaging and siRNA delivery.

Keywords:non-toxic quantum dots;sonochemistry;siRNA delivery;stem cell imaging;nanomaterial libraries

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논문정보   
- 형식: Research article
- 게재일: 2012년 06월 (BRIC 등록일 2012-07-06)
- 연구진: 국내(교신)+국외 연구진태극기
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