Northwestern University, 현 Rutgers, The State University of New Jersey

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Protein Nanoarrays Generated By Dip-Pen Nanolithography
Ki-Bum Lee,(1)1So-Jung Park,(1)Chad A. Mirkin,(1)*Jennifer C. Smith,(2) Milan Mrksich(2)*

Dip-pen nanolithography was used to construct arrays of proteins with 100- to 350-nanometer features. These nanoarrays exhibit almost no detectable nonspecific binding of proteins to their passivated portions even in complex mixtures of proteins, and therefore provide the opportunity to study a variety of surface-mediated biological recognition processes. For example, reactions involving the protein features and antigens in complex solutions can be screened easily by atomic force microscopy. As further proof-of-concept, these arrays were used to study cellular adhesion at the submicrometer scale.

(1) Northwestern University, Department of Chemistry and Center for Nanofabrication and Molecular Self-Assembly, 2145 Sheridan Road, Evanston, IL 60208, USA.

(2)University of Chicago, Department of Chemistry and the Institute for Biophysical Dynamics, 5735 South Ellis, Chicago, IL 60637, USA.

* To whom correspondence should be addressed.
주소복사
논문정보   
- 형식: Research article
- 게재일: 2002년 03월 (BRIC 등록일 2004-02-16)
- 연구진: 국외연구진
- 분야: 생물학관련 모든분야
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