Rutgers, The State University of New Jersey

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이메일
Selective Inhibition of Human Brain Tumor Cells through Multifunctional Quantum-Dot-Based siRNA Delivery
펼치기 Authors and Affiliations
Abstract

More than one job: Quantum dots (QDs) conjugated with thiol-modified small interfering RNA (siRNA) were functionalized with thiol-modified RGD and HIV-Tat peptides. These multifunctional QDs were used for the targeted delivery and tracking of siRNA molecules for the knockdown of the EGFRvIII gene, which led to the down-regulation of the PI3K-Akt signaling pathway and the apoptosis of malignant brain cancer cells.

Keywords
antitumor agents, gene knockdown, nanoparticles, nonviral siRNA delivery, target-specific delivery
 

주소복사
논문정보   
- 형식: Research article
- 게재일: 2009년 12월 (BRIC 등록일 2009-12-11)
- 연구진: 국외연구진
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