BioLab
BioWave,  Vol. 25 No. 7
고려대학교 바이오시스템의과학부 Cell Death & Metabolism Lab 김성은 교수
연구실 홈페이지
Introduction  
 

 Our group is interested in understanding metabolic pathways and cell death programs that are altered in human diseases and to employ this knowledge towards developing novel therapeutic strategies.

 

   김성은 (Sung Eun Kim, Ph.D.)
   Assistant Professor, School of Biosystems and Biomedical Sciences, Korea University

  2019- Assistant Professor, School of Biosystems and Biomedical Sciences, Korea University
  2016-2019 Helen Diller Cancer Center, University of California San Francisco, USA (Postdoc)
  2009-2016 Cell and Developmental Biology, Weill Cornell Medical College & MSKCC, USA (Ph.D.)
  2006-2008 Animal Biotechnology and Genetic Engineering, Korea University, Korea (M.S.)
  2002-2006 Biotechnology and Genetic Engineering, Korea University, Korea (B.S.)

 
 
Research  
 

1. Cancer metabolism

It is well known that cancer cells rewire their metabolism to obtain a survival advantage in nutrient-deprived conditions. In particular, cancer cells are notorious for upregulating various metabolic pathways for nutrient scavenging, such as autophagy or macropinocytosis. Also, these cells can regulate nutrient transporters to gain a survival advantage. We are interested in studying the underlying mechanisms for these reprogrammed metabolic pathways and further exploiting them for therapeutic treatments.

 

2. Ferroptosis

Initiating cell death in cancers is the ultimate goal of many cancer therapeutics. Ferroptosis is a non-apoptotic cell death program that is caused by lipid peroxidation in an iron-dependent manner. We are interested in studying the mechanism of ferroptosis and its regulation in disease states such as cancer or degenerative diseases.

 
 
Publications  
 

최근 5년, 2019~현재

- 2022
Kim SH, Song JH, Kim MJ, Song MG, Ku AA, Bandyopadhyay S, McCormick F, Kim SE* (2022) Novel regulators of macropinocytosis-dependent growth revealed by Informer Set library screening in pancreatic cancer cells. Metabolites 12(9):831. doi: 10.3390/metabo12090831. PMID: 36144235.

Lee YS, Kwon O, Jeong GR, Noh J, Kim SE, Yi GS, Hwang EM, Park JY* (2022) Deficiency of TTYH1 expression reduces the migration and invasion of U2OS human osteosarcoma cells. Life 12(4):530. doi: 10.3390/life12040530. PMID: 35455021.

- 2021
Kim SH, Wolfe A, Kim SE* (2021) Targeting cancer's sweet spot: UGP2 as a therapeutic vulnerability. Mol Cell Oncol 8(6):1990676. doi: 10.1080/23723556.2021.1990676. PMID: 35419477.

Kim SE*, Zhang J, Jiang E, Overholtzer M* (2021) Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells. FASEB J 35(10):e21909. doi: 10.1096/fj.202100870R. PMID: 34547144.

Wolfe AL, Zhou Q, Toska E, Galeas J, Ku AA, Koche RP, Bandyopadhyay S, Scaltriti M, Lebrilla CB, McCormick F*, Kim SE* (2021) UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. PNAS 118(31):e2103592118. doi: 10.1073/pnas.2103592118. PMID: 34330832.

Kim MJ, Yun GJ, Kim SE* (2021) Metabolic regulation of ferroptosis in cancer. Biology (Basel) 10(2):83. PMID: 33499222.

Kim SW, Kim Y, Kim SE*, An JY* (2021) Ferroptosis-related genes neurodevelopment and central nervous system. Biology (Basel) 10(1):35. PMID: 33419148.

- 2020
Kwak SY, Seo IH, Chung IH, Kim SA, Lee JO, Lee HJ, Kim SE, Han JA, Kang MJ, Kim SJ, Lim S, Kim KM, Chung JH, Lim E, Hwang JI, Kim HS*, Shin MJ* (2020) Effect of chitinase-3-like protein 1 on glucose metabolism: In vitro skeletal muscle and human genetic association study. FASEB J 34(10):13445-13460. PMID: 32816366.

- 2019
Wang MT, Fer N, Galeas J, Collisson EA, Kim SE, Sharib J, McCormick F* (2019) Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Nat Commun 10(1):3055. PMID: 31296870.

Hamann JC, Kim SE, Overholtzer M* (2019) Methods for the study of entotic cell death. Methods Mol Biol 1880:447-454. PMID: 30610714.
 
     
 
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확대보기  

 지도교수: 김성은 교수

   (2022년 현재)
 Graduate Students MS-PhD program : 김성훈, 윤지호, 박세흠
 Graduate Students MS program : 김민지, 송재호, 김상훈, 김희연
 Undergraduate Students : Daria Bondar
 Contact : sek19@korea.ac.kr
 Homepage: https://kimlab-ku.weebly.com/
 
     
* 본 정보는 해당 대학/연구실에서 제공하는 자료를 바탕으로 구성된 내용으로, BRIC에서 작성한 정보가 아님을 밝힙니다.
* 소개된 내용에서 중요하게 판단되는 부분은 해당 기관에 추가적으로 사실 확인 작업을 하시길 부탁드립니다.
* 내용의 업데이트 또는 변경을 원하시면 관리자(news@ibric.org)에게 연락 바랍니다.
등록일 2023.01.16
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