BioWave,  Vol. 25 No. 5
한양대학교 생명공학과 세포 및 나노치료제 공학 연구실 박희호 교수
연구실 홈페이지
Introduction  
 

 우리 실험실에서는 산업, 의학적으로 유용한 세포 및 생물학적 기반 생체재료 물질 생산을 위한 연구를 수행하고 있습니다. 우리가 살고 있는 시대는 세포 및 생체재료 기반 나노치료제가 각광을 받고 있으며, 이 두 기술의 결합으로 다양한 분야에서 시너지 효과를 창출해나가고 있습니다. 이런 시대의 흐름으로 볼 때, 세포 및 나노치료제를 이용한 바이오공학 기반 연구 및 응용분야로의 확장은 필수적이라고 할 수 있습니다. 본 연구실은 동물 및 미생물 유래 생체재료 기반 나노치료제를 적용하여 인간의 삶의 질을 높이는데 기여하고자 합니다.

   Hee Ho Park, Ph.D.
   Assistant Professor, Department of Bioengineering Hanyang University(Sep. 2021 - Current)

   - Assistant Professor, Division of Chemical Engineering and Bioengineering, Kangwon National University,
     Korea (Mar. 2018 - Aug. 2021)
   - Postdoctoral Research Fellow, Div. of Hematology/Oncology, Boston Children’s Hospital Harvard Medical
      School, Boston, USA(Advisor: Prof. David A. Williams & Prof. Christian Brendel)(May. 2016 - Feb. 2018)
  - Postdoctoral Research Fellow, The Institute of Molecular Biology & Genetics, Seoul National University,
     Korea(Advisor: Prof. Byung-Gee Kim, Prof. Tai Hyun Park)(Sep. 2014 - Apr. 2016)
  - Technical Research Personnel, The Institute of Molecular Biology & Genetics, Seoul National University,
     Korea (Advisor: Prof. Byung-Gee Kim ) (Mar. 2013 - Feb. 2016 )
  - Technical Research Personnel, School of Chemical and Biological Engineering,, Seoul National University,
     Korea(Advisor: Prof. Tai Hyun Park) (Mar. 2013 - Feb. 2016 )
   - Ph. D., School of Chemical and Biological Engineering, Seoul National University, Korea(Advisor: Prof. Tai Hyun Park)(Sep. 2007 - Aug. 2014)
   - Master of Engineering, Department of Chemical Engineering, Imperial College London, United Kingdom
    (Advisor: Prof. Athanasios (Sakis) Mantalaris, Currently @ Georgia Institute of Technology)(Oct. 2003 - Jun. 2007)

 

 
Research  
 

 

Publications  
 

최근 3년, 2020~2022

[ 2022 ]
Ryu, J.1, Yang, S. J.1, Son, B., Lee, H., Lee, J., Joo, J., Park, H.H.*, Park, T. H.* (2022) "Enhanced anti-cancer effect using MMP-responsive L-asparaginase fused with cell-penetrating 30Kc19 protein", Artificial Cells Nanomedicine and Biotechnology, Accepted (IF 6.355, JCR 상위 15%)
* Co-corresponding author

Yoo, J.1, Kim, K.1, Kim, S., Park, H. H.*, Shin, H.*, Joo, J.* (2022) "Tailored polyethylene glycol grafting on porous nanoparticles for enhanced targeting and intracellular siRNA delivery", Nanoscale, Accepted (IF 8.307, JCR 상위 15%)
* Co-corresponding author

Son, B.1, Yoon, H.1, Ryu, J., Lee, H., Joo, J., Park, H.H.*, Park, T. H.* (2022) "Enhanced efficiency of generating human induced pluripotent stem cells using Lin28-30Kc19 fusion protein", Frontiers in Bioengineering and Biotechnology, Accepted (IF 6.064, JCR 상위 10%)
* Co-corresponding author

Lee, G.1, Kim, S. J.1, , Kim, E. M., Kim, E., Lee, S., Lee, E., Park, H. H.*, Shin, H.* (2022) "Free radical-scavenging composite gelatin methacryloyl hydrogels for cell encapsulation", Acta Biomaterialia, Accepted (IF 10.633, JCR 상위 10%)
* Co-corresponding author

Kim, H.1, Son, B. R.1, Seo, E. U.1, Kwon, M., Ahn, J. H., Shin, H., Song, G. Y., Park, E. J., Na, D. H., Cho, S. W., Kim, H. N.*, Park, H. H.*, Lee, W.* (2022) "Cleavage-responsive biofactory T cells suppress infectious diseases-associated hypercytokinemia", Advanced Science, Accepted (IF 17.521, JCR 상위 5%)
* Co-corresponding author

Son, B.1, Lee, S. H.1, Hong, S., Kwon, M., Joo, J., Lim, K. S.*, Park, H.H.* (2022) "Direct conversion of bovine dermal fibroblasts into myotubes by viral delivery of transcription factor bMyoD", Applied Sciences, Accepted
* Co-corresponding author

Yoo, W.1, Lee, W.1 , Kim, H. N.1, Jeong, J.1, Park, H. H., Jung, D., Ahn, J. H., Lee, J., Kim, J., Lee, S. W.*, Cho, W. S.*, Kim, S.* (2022) "Nanodiamond as a cytokine sponge in infectious diseases", Frontiers in Bioengineering and Biotechnology, 504

Wang, C. P., Byun, M. J., Kim, S. N., Park, W., Park, H. H., Kim, T. H., Lee, J. S., Park, C. G.* (2022) "Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment", Journal of Controlled Release, In Press

Kim, E. M., Lee, G. M., Lee, S., Kim, S., Lee, D., Yoon, D. S., Joo, J., Kong, H., Park, H. H.*, Shin, H.* (2022) "Effects of mechanical properties of gelatin methacryloyl hydrogels on encapsulated stem cell spheroids for 3D tissue engineering", International Journal of Biological Macromolecules, 194, 903-913 (IF 6.953, JCR 상위 10%)
* Co-corresponding author

 

[ 2021 ]
Kang, M.1, Lee, S.H.1, Kwon, M., Byun, J., Kim, D., Kim, C., Koo, S., Kwon, S. P., Moon, S., Jung, M., Hong, J., Go, S., Song, S. Y., Choi, J. H., Hyeon, T., Oh, Y.K., Park, H. H.*, Kim, B. S.* (2021) "Nanocomplex-mediated in vivo programming to chimeric antigen receptor-M1 macrophages for cancer therapy", Advanced Materials, 2103258 (IF 30.849, JCR 상위 3%)
* Co-corresponding author

Jeong, H.1, Kim, W.1, Choi, D., Heo, J., Han, U., Jung, S. Y., Park, H. H., Hong, S. T., Park, J. H.*, Hong, J.* (2021) "Potential threats of nanoplastic accumulation in human induced pluripotent stem cells", Chemical Engineering Journal, 427, 131841

Choi, K., Lee, S. H., Kwon, M., Hong, S., Park, H. H., Lim, K. S.* (2021) "Development of Anticancer Chemotherapy: Inhibitors of Topoisomerase, HSP90, mTOR and Tyrosine Kinase", KSBB Journal, 36, 2, 99-117

Kim, H.1, Lee, H.1, Ahn, J. H.1, An, J., Hong, K. S., Jang, J. G., An, J., Mun, Y. H., Yoo, S. Y., Choi, Y. J., Yun, M. Y., Song, G. Y., Joo, J., Na, D. H.*, Kim, H. N.*, Park, H. H.*, Lee, J. Y.*, Lee, W.* (2021) "Lung-selective 25-hydroxycholesterol nanotherapeutics as a suppressor of COVID-19-associated cytokine storm", Nano Today, 101149 (IF 20.722, JCR 상위 5%)
* Co-corresponding author

Heo, J.1, Choi, J.1, Kim, J. Y., Jeong, H., Choi, D., Han, U., Park, J. H., Park, H. H.*, Hong, J.* (2021) "2D graphene oxide particles induce unwanted loss in pluripotency and trigger early differentiation in human pluripotent stem cells", Journal of Hazardous Materials, 125472 (IF 10.588, JCR 상위 3%)
* Co-corresponding author

Park, H. H.1, Kim, H.1, Lee, H.1, Seo, E. U.1, Kim, J. E.1, Lee, J. H., Mun, Y. H., Yoo, S. Y., An, J., Yun, M. Y., Kang, N. W., Kim, D. D., Na, D. H., Hong, K. S., Jang, J. G., Ahn, J. H., Bae, J. S.*, Song, G. Y.*, Lee, J. Y.*, Kim, H. N.*, Lee, W.* (2021) "PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses", Biomaterials, 120827 (IF 12.479, JCR 상위 3%)

Lee, S., Lee, J., Byun, H., Kim, S., Joo, J., Park, H. H., Shin, H.* (2021) "Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering", Acta Biomaterialia, 124, 166-178

Choi, D. W.1, Roh, Y. J.1, Kim, S.1, Lee, H. M., Kim, M., Shin, D., Park, J. H., Park, H. H., Ok, Y. S., Kang, D., Kim, J. H, Tarrago, L., Danial, N. N., Gladyshev, V. N., Min, P. K.*, Lee, B. C.* (2021) "Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues", Biosensors and Bioelectronics, 113031

Lee, Y. Y.1, Park, H. H.1, Park, W.1, Kim, H.1, Jang, J. G., Hong, K. S., Lee, J. Y., Seo, H. S., Na, D. H., Kim, T. H., Choy, Y. B., Ahn, J. H.*, Lee, W.*, Park, C. G.* (2021) "Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm" Biomaterials, 267, 120389 (IF 10.317, JCR 상위 3%)
1 Co-first author

 

[ 2020 ]
Cha, H.1, Hong, S.1, Park, J. H.*, Park, H. H.* (2020) "Stem cell-derived exosomes and nanovesicles: Promotion of cell proliferation, migration and anti-senescence for treatment of wound damage and skin ageing", Pharmaceutics, 12, 12, 1135

Cha, H.1, Lee, J.1, Park, H. H.*, Park, J., H.* (2020) "Direct conversion of human fibroblasts into osteoblasts triggered by histone deacetylase inhibitor valproic acid", Applied Sciences, 10, 20, 7372
* Co-corresponding author

Park, H. H.1, Park, W.1, Lee, Y. Y.1, Kim, H., Seo, H. S., Choi, D. W., Kwon, H. K., Na, D. H., Kim, T. H., Choy, Y. B., Ahn, J. H.*, Lee, W.*, Park, C. G.* (2020) "Bioinspired DNase-I-coated melanin-like nanospheres for modulation of infection-associated NETosis dysregulation", Advanced Science, 7, 2001940 (IF 15.840, JCR 상위 5%)

Kim, H. N.1, Park, H. H.1, Lim, W.1, Hong, K. S., Ahn, J. H., Na, D. H., Kim, I. S., Jang, J. G.*, Bae, J. S.*, Lee, W.* (2020) "Ferritin nanocage-based methyltransferase SETD6 for COVID-19 therapy", Advanced Functional Materials, 30, 2006110 (IF 16.836, JCR 상위 5%)
1 Co-first author

Lee, H.1, Kim, S.1, Yoon, H., Ryu, J., Park, H. H., Hwang, N. S.*, Park, T. H.* (2020) "Intracellular delivery of recombinant RUNX2 facilitated by cell-penetrating protein for the osteogenic differentiation of hMSCs", ACS Biomaterials Science and Engineering, 6, 9, 5202-5214

Lee, W.1, Ahn, J. H.1, Park, H. H.1, Kim, H. N.1, Kim, H., Yoo, Y., Shin, H., Hong, K. S., Jang, J. G., Park, C. G., Choi, E. Y. *, Bae, J. S.*, Seo, Y. K.* (2020) "COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm", Signal Transduction and Targeted Therapy, 5, 1, 1-11 (IF 13.493, JCR 상위 3%)
1 Co-first author

Choi, E. Y.1, Park, H. H.1, Kim, H.1, Kim, H., N., Kim, I., Jeon, S., Kim, W.*, Bae, J. S.*, Lee, W.* (2020) "Wnt5a and Wnt11 as acute respiratory distress syndrome biomarkers for SARS-CoV-2 patients", European Respiratory Journal, 56, 5, 2001531 (IF 12.339, JCR 상위 6%)
1 Co-first author

Park, H., Kwon, M., Kwang Suk Lim*, Park, H. H.* (2020) "Chimeric Antigen Receptor-T cell (CAR-T) therapy targeting hematologic malignancy", KSBB Journal, 35, 3, 183-191

Park, H. H.1, Kim, H. N.1, Kim, H.1, Yoo, Y., Shin, H., Choi, E. Y. *, Bae, J. S. *, Lee, W.* (2020) "Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia", Science Advances, 6, 31, eabc1564 (IF 13.117, JCR 상위 5%)
1 Co-first author

Yu, H.1, Hong, S.1, Kwon, M., Lee, J., Park, H., H., Lim, K. S.* (2020) "Therapeutic antibodies for the treatment of cancer: Cancer Immunotherapy", KSBB Journal, 35, 2, 105-119

Kwon, M., Park, H. H.* (2020) "CAR-T therapy targeting solid tumor", KSBB Journal, 35, 2, 95-104

Hong, S.1, Choi, D. W.1, Kim, H. N.1, Park, C. G.*, Lee, W.*, Park, H. H.* (2020) "Protein-based nanoparticles as drug delivery systems", Pharmaceutics, 12, 7, 604

Lee, J., Lim, K. S., Park, H. H., Ha, S. J.* (2020) "A qualitative case study on the teaching experiences of biotechnology-related curriculum linked extracurricular program management", The Korean Society of Culture and Convergence, 42, 5, 729-758

Hong, S., Park, H. H.* (2020) "Drug delivery system using protein nanoparticles", KSBB Journal, 35, 1, 10-22

Ryu, J., Hwang, N. S., Park, H. H.*, Park, T. H.* (2020) "Protein-based direct reprogramming of fibroblasts to neuronal lineage cells", International Journal of Biochemistry and Cell Biology, 121, 105717
* Co-corresponding author

 

 
     
 
멤버사진
확대보기  

 지도교수: 박희호 교수

   (2022년 현재)
 Postdoc : 손보람
 Master student : 원효섭, 김진구, 박광열, 조현진, 정아형, 한다솜, 김지현, 장나영, 신영은
 Intern : 정유진
 Administrative staff : 이희라
 Contact :
parkhh@hanyang.ac.kr , Lab: 02-2220-4097
 Homepage: https://www.cntlaboratory.com/

 
     
* 본 정보는 해당 대학/연구실에서 제공하는 자료를 바탕으로 구성된 내용으로, BRIC에서 작성한 정보가 아님을 밝힙니다.
* 소개된 내용에서 중요하게 판단되는 부분은 해당 기관에 추가적으로 사실 확인 작업을 하시길 부탁드립니다.
* 내용의 업데이트 또는 변경을 원하시면 관리자(news@ibric.org)에게 연락 바랍니다.
등록일 2022.12.12
주소복사
HOME   |   이용약관   |   개인정보처리방침
© BRIC