BioWave,  Vol. 25 No. 5
이화여자대학교 자연과학대학 화학생명분자과학부 Nano-Bio Materials Laboratory 박소정 교수
연구실 홈페이지

 The Park group’s research focuses on developing methods to control the organization of nanoparticles and polymers and to construct functional hybrid materials with controllable structure and properties. In particular, we use biomimetic approach to control the arrangement of nanoparticles and polymers of various compositions (e.g., conjugated polymers, peptides, and DNA). Our primary interest is to learn how to manipulate properties of inorganic nanoparticles, optoelectronic polymers, and DNA through the self-assembly.

So-Jung Park
Professor - Department of Chemistry and Nanoscience, Ewha Womans University

 Dr. So-Jung Park is a professor in the department of chemistry and nanoscience at Ewha womans university. She obtained her Ph.D. in Chemistry at Northwestern University in 2002 under the guidance of Prof. Chad Mirkin with a thesis on DNA-mediated assembly of nanostructured materials: structure, properties, and biodetection applications. Her PhD work was recognized by several prestigious awards including the ACS Nobel signature award. She then carried out her postdoctoral research with Prof. Paul Barbara at University of Texas at Austin, where she developed a new technique that allows for single molecule optical measurements correlated with electrical modulation for photophysical studies of semiconducting polymers and nanocrystals. She joined the faculty of the department of chemistry at the University of Pennsylvania as an assistant professor in the fall of 2005 and promoted to an associate professor with tenure in 2012. She then moved to Ewha woman’s university as a professor in 2013. Her research focuses on self-assembly of nanoparticles and functional polymers and their applications in biomedicine and optoelectronic devices. Her current research topics includes 1) colloidal self-assembly of nanoparticles and block-copolymers, 2) functional block copolymers (e.g., DNA, conjugated polymers), 3) plasmonic nanoparticles, and 4) dynamic nanostructures. The research projects aim to understand collective behaviour of nanomaterials and to develop new functional materials through self-assembly. She has received the NSF career award, ARO young investigator award, and Camille Dreyfus Teacher Scholar Award. She is serving as an associate editor for ACS Applied Materials & Interfaces and an advisory board member for Nanoscale.

Research Highlight  

01. Nanoparticle-Directed Self-Assembly of Block Copolymers

Superparamagnetic Polymersomes
The incorporation of nanoparticles induce interesting morphology changes in self-assembly of amphiphilic polymers. For example, we have fabricated polymersomes densely packed with magnetic nanoparticles through cooperative self-assembly of nanoparticles and micelle-forming polymers. The superparamagnetic polymersomes exhibited significantly enhanced magnetic relaxivity than typical micellar structures. [Angew. Chem. Int. Ed. 2007, 46, 48, 9235-9238, JACS, 2011, 133, 1517-1525, ACS Nano, 2013, 7, 5824, ACS Nano. 2014, 8, 495-502.]

Nanoporous Films
We investigated self-assembly of nanoparticles and block copolymers at the air-water interface, which led to the formation of highly uniform composite films with interesting nanoscale porous structures. [ACS Nano, 2020, 14, 12203.]


02. Self-Assembly of Conjugated Block-Copolymer

Hierarchical Self-Assembly of Conjugated Block-Copolymers
Solution phase self-assembly of P3HT-b-PEO led to various types of hierarchical assembly structures of P3HT nanofibers, demonstrating that the supramolecular self-assembly of conjugated polymers provides a new toolbox for the formation of functional organic nanostructures. [JACS, 2010, 132, 9931, ACS Nano. 2012, 6, 2844]

Air-Liquid Interfacial Self-Assembly of Conjugated Block-Copolymers
Interfacial self-assembly of P3HT-b-PEO was used to fabricate ultrathin conjugated polymer films composed of well-aligned P3HT nanowires. Furthermore, binary self-assembly with functional nanoparticles led to ordered arrays of functional nanoparticles and polymers with improved transport properties. [ACS Nano 2014, 8, 12755, ACS AMI 2019, 11, 28538, ACS AMI 2020, 12, 5099, ACS AMI 2022]


03. DNA Block-Copolymers

Low-Dimensional DNA Nanostructures
Unusual low-dimensional DNA nanostructures were fabricated from DNA-b-poly(amino acid) through programmable and sequence-specific peptide interactions. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions (ACS Nano 2020, 14, 2276).


Janus Nanosheets
Janus DNA nanosheets were fabricated from molecular building blocks composed of two information-carrying biopolymers, DNA and peptides. Experimental and structural modeling studies reveal that DNA1-peptide-DNA2 conjugates assemble into Janus nanosheets presenting two different DNA on opposite faces. The surprising level of structural control is attributed to the exclusive parallel β-sheet formation of phenylalanine-rich peptides. (Small 2021, 17, 2006110).


04. Plasmonic Nanoparticles

Spiky Gold Nanoshells
We developed a new synthetic method for metal nanoshells with highly structured surface. They exhibit enhanced near-field and far-field scattering compared to widely studied smooth shells and serve as highly reproducible and bright surface-enhanced Raman scattering (SERS) substrate. [J. Phys. Chem. C 2012, 116, 10318(Featured on the journal cover), ACS Nano, 2014, 8, 9, 9025-9034.]

Assembly of metal nanoparticles can bring about unusual metamaterial properties that are rarely observed in our surroundings. The synthetic method allows for simultaneous synthesis and assembly of nanoparticles to fabricate raspberry-like metamolecules supporting strong magnetic resonances. [ACS Nano 2015, 9, 1263, J. Phys. Chem. C 2020, 124, 20436?20444(Editor's choice), Adv. Mater. 2021, 2007668.]


05. DNA-Mediated Layer-by-Layer Assembly for Dynamic Nanostructures

Responsive Free-Standing Nanoparticle Films
Responsive free standing films of gold nanoparticles were fabricated by a new approach based on the programmable DNA-directed self-assembly and the layer-by-layer (LbL) thin film fabrication technique. [Nano Lett., 2013, 13, 4449, Nat. Nanotech., 2017, 12, 41]. We further combined the strategy with plasmonic photopatterning to fabricate nanoparticle films with vertical and lateral heterogeneity, which showed complex morphing actions instructed by the lateral and vertical patterns inscribed in the film as well as the information carried in DNA [Adv. Mater., 2022].


최근 3년, 2020~2022

- 2022

"Free-Standing Two-Dimensional Sheets of Polymer-Linked Nanoparticles"
Xiaole Hu,a Ji-eun Park, Seulki Kang, Chan-Jin Kim, Youngji Kim, Jerome Kartham Hyun and So-Jung Park*, Nanoscale, 2022,

"Conjugated Block Copolymers for Functional Nanostructures"
Seulki Kang, Ga-Hyun Kim, and So-Jung Park*, Acc. Chem. Res, 2022,

"Spatial Organization of Photocatalysts and Enzymes on Janus-Type DNA Nanosheets for Efficient CO2 Conversion"
Pegah Tavakoli Fard, Shine K. Albert, Jein Ko, Sohyun Lee, So-Jung Park*, and Jinheung Kim*, ACS Catal, 2022, 12, 9698-9705

"Heterogeneity in Dynamic Metamolecules"
Sunghee Lee, Omar Ibrahim, Zahra Fakhraai*, and So-Jung Park*, J. Phys. Chem. C, 2022, 126, 15, 6668-6677

"Shape-Changing DNA-Linked Nanoparticle Films Dictated by Lateral and Vertical Patterns"
Jongwook Kim, Sunghee Lee, Jisu Choi, Kyungnae Baek, Tae Soup Shim, Jerome Kartham Hyun, and So-Jung Park*, Adv. Mater, 2022, 34, 13, 2109091

"Magnetic Field-Induced Self-Assembly of Conjugated Block Copolymers and Nanoparticles at the Air-Water Interface"
Minkyeong Park, Seulki Kang, Chongyong Nam, Karnati Narasimha, Won Bo Lee, and So-Jung Park*, ACS Appl. Mater. Interfaces, 2022, 14, 6, 8266-8273

"In Situ Liquid Phase TEM of Nanoparticle Formation and Diffusion in a Phase-Separated Medium"
Youngju Son, Byung Hyo Kim, Back Kyu Choi, Zhen Luo, Joodeok Kim, Ga-Hyun Kim, So-Jung Park, Taeghwan Hyeon,* Shafigh Mehraeen,* and Jungwon Park, ACS Appl. Mater. Interfaces, 2022,

"Optically Left-Handed Nanopearl Beads with Inductance-Capacitance Circuits at Visible-Near-Infrared Frequencies Based on Scalable Methods"
Seung Beom Pyun, Min Gyu Kim, Sung Wook Kim, Ji Eun Song, Hyun Ik Jeon, Sangho Kim, So-Jung Park, and Eun Chul Cho*, ACS Appl. Mater. Interfaces, 2022, 14, 5, 7121-7129


- 2021

"Real-Space Imaging of Nanoparticle Transport and Interaction Dynamics by Graphene Liquid Cell TEM"
Sungsu Kang, Ji-Hyun Kim, Minyoung Lee, Ji Woong Yu, Joodeok Kim, Dohun Kang, Hayeon Baek, Yuna Bae, Byung Hyo Kim, Seulki Kang, Sangdeok Shim, So-Jung Park, Won Bo Lee, Taeghwan Hyeon, Jaeyoung Sung*, Jungwon Park*, Sci. Adv, 2021, 7, 49, eabi5419

"Hypothermic Stem Cell Storage Using a Polypeptide Thermogel"
Zhengyu Piao, Jin Kyung Park, So-Jung Park, and Byeongmoon Jeong*, Biomacromolecules, 2021, 22, 12, 5390-5399

"Nanoparticle Cellular Internalization is Not Required for RNA Delivery to Mature Plant Leaves"
Huan Zhang, Natalie S. Goh, Jeffrey W. Wang, Rebecca L. Pinals, Eduardo Gonzalez-Grandio, Gozde S. Demirer, Salwan Butrus, Sirine C. Fakra, Antonio Del Rio Flores, Rui Zhai, Bin Zhao, So-Jung Park and Markita P. Landry*, Nat. Nanotechnol, 2021, 17, 197-205

"Optical Magnetic Multipolar Resonances in Large Dynamic Metamolecules"
Omar Ibrahim*, Sunghee Lee, Sung Wook Kim, Seung Beom Pyun, Connor Woods, Eun Chul Cho, So-Jung Park, and Zahra Fakhraai*, J. Phys. Chem. C, 2021, 125, 30, 16605-16619

"Size and Shape Control of Ice Crystals by Amphiphilic Block Copolymers and Their Implication in the Cryoprotection of Mesenchymal Stem Cells"
Jin Kyung Park, Madhumita Patel, Zhengyu Piao, So-Jung Park, and Byeongmoon Jeong*, ACS Appl. Mater. Interfaces, 2021, 13, 29, 33969-33980

"The Core Composition of DNA Block Copolymer Micelles Dictates DNA Hybridization Properties, Nuclease Stabilities, and Cellular Uptake Efficiencies"
Chan-Jin Kim, Ga-Hyun Kim, Eun Hye Jeong, Hyukjin Lee and So-Jung Park*, Nanoscale, 2021, 13, 32, 13758-13763

"Concurrent Imaging of Surface-Enhanced Raman and Mie Scattering from Built-in Nanogap Plasmonic Particles"
Sunghee Lee, Jungwoo Kim, Kyungnae Baek, Nam Hoon Kim, Jerome K. Hyun*, So-Jung Park* and Haemi Lee*, Phys. Chem. Lett, 2021, 12, 25, 5889-5896

"Molecular-Level Control of Intersheet Distance and Electronic Coupling between 2D Semiconducting and Metallic Nanosheets: Establishing Design Rules for High-Performance Hybrid Photocatalyst"
Tae-Ha Gu, Xiaoyan Jin, So-Jung Park, Min Gyu Kim, Seong-Ju Hwang*, Adv. Sci, 2021, 8, 7, 2004530

"Synthesis, Assembly, Optical Properties, and Sensing Applications of Plasmonic Gap Nanostructures"
Jae-Myoung Kim, Chungyeon Lee, Yeonhee Lee, Jinhaeng Lee, So-Jung Park, Sungho Park, and Jwa-Min Nam*, Adv. Mater, 2021, 33, 46, 2006966

"Controlled Assembly of Plasmonic Nanoparticles: from Static to Dynamic Nanostructures"
Sunghee Lee, Kyunjong Sim, So Yoon Moon, Jisu Choi, Yoojung Jeon, Jwa-Min Nam*, and So-Jung Park*, Adv. Mater, 2021, 33, 46, 2007668

"Janus Nanosheets with Face-Selective Molecular Recognition Properties from DNA-Peptide Conjugates"
Shine K. Albert, Sunghee Lee, Prasannavenkatesh Durai, Xiaole Hu, Byeongmoon Jeong, Keunwan Park*, and So-Jung Park*, Small, 2021, 17, 12, 2006110

"Correlating 3D Surface Atomic Structure and Catalytic Activities of Pt Nanocrystals"
Sungin Kim, Jimin Kwag, Chiara Machello, Sungsu Kang, Junyoung Heo, Cyril F. Reboul, Dohun Kang, Seulki Kang, Sangdeok Shim, So-Jung Park, Byung Hyo Kim, Taeghwan Hyeon, Peter Ercius*, Hans Elmlund*, and Jungwon Park*, Nano Lett, 2021, 21, 2, 1175-1183

"Responsive Thin-Film Interference Colors from Polaronic Conjugated Block Copolymers"
Cheon Woo Moon, Ji-eun Park, Minkyeong Park, Youngji Kim, Karnati Narasimha, Jerome Kartham Hyun*, and So-Jung Park*, ACS Appl. Mater. Interfaces, 2021, 13, 1, 1555-1561


- 2020

"Nanoparticle-Induced Self-Assembly of Block Copolymers into Nanoporous Films at the Air-Water Interface"
Seulki Kang, Du Yeol Ryu, Emilie Ringe, Robert J. Hickey, and So-Jung Park*, ACS Nano, 2020, 14, 9, 12203-12209

"Distinct Optical Magnetism in Gold and Silver Probed by Dynamic Metamolecules"
Sunghee Lee, Connor N. Woods, Omar Ibrahim, Sung Wook Kim, Seung Beom Pyun, Eun Chul Cho, Zahra Fakhraai, and So-Jung Park*, J. Phys. Chem. C, 2020, 124, 37, 20436-20444

"Synthesis and Single-Particle Surface-Enhanced Raman Scattering Study of Plasmonic Tripod Nanoframes with Y-Shaped Hot-Zones"
Jeongwon Kim, Sungjae Yoo, Jae-Myoung Kim, Sungwoo Choi, Juri Kim, So-Jung Park, Doojae Park, Jwa-Min Nam, and Sungho Park*, Nano Lett, 2020, 20, 6, 4362-4369

"Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures"
Chan-Jin Kim, Ji-eun Park, Xiaole Hu, Shine K. Albert, and So-Jung Park*, ACS Nano, 2020, 14, 2, 2276-2284

"Long-Range Order Self-Assembly of Conjugated Block Copolymers at Inclined Air-Liquid Interfaces"
Saejin Oh, Seulki Kang, Ma. Helen M. Cativo, Myungjae Yang, Sung-Hee Chung, Jeongsu Kim, Jean Bouffard, Seunghun Hong*, and So-Jung Park*, ACS Appl. Mater. Interfaces, 2020, 12, 4, 5099-5105


 지도교수: 박소정 교수

   (2022년 현재)
 Research Professor : Ji-eun Park
 Post-Doctoral Fellow : Shine K. Albert, Jong Wook Kim, Murali Golla, Gourab Bhattacharjee
 Graduate Student : Sunghee Lee, Seulki Kang, Gahyun Kim, Hyojung Kang, Soyun Lee, Jin-Young Park
    Minkyeoung Kim, Jein Ko, Hyunjin Jeon, Soojin Hwang, Seonju Park
 Contact :, Lab: 02-3277-4191

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등록일 2022.12.05
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