BioWave,  Vol. 25 No. 4
연세대학교 시스템생물학과 Molecular Structure & Signaling Lab 신동혁 교수
연구실 홈페이지
Introduction  
 

 본 분자 구조 및 신호 전달 연구실은 감염병 바이러스 (코로나, 인플루엔자 바이러스 등) 단백질의 구조및 생화학 연구, 감염균과 숙주간의 단백질 상호작용에 대한 연구, 감염균 (박테리아 또는 바이러스)으로 부터 유래된 유비퀴틴 (Ubiquitin) 시스템 관련 연구를 진행하고 있습니다.

   Donghyuk Shin, Ph. D.
   Assistant Professor, Yonsei University, South Korea (Mar. 2021 - )

   Assistant Professor, Incheon National University, South Korea (Sep. 2020 - Feb.2021)
   Postdoctoral Research Fellow, Max-Planck Institute of Biophysics, Frankfurt am Main, Germany
    (Oct. 2018 -Aug. 2020 ) - Ivan Dikic's Group
   Postdoctoral Researcher, Institute of Biochemistry II, Medical Faculty, Goethe University
    (Nov. 2017 - Sep. 2018) - Ivan Dikic's Group
   Postdoctoral Researcher, Sungkyunkwan University (Sep. 2017 - Oct. 2017)
   Ph.D., Sungkyunkwan University, Korea (2017)
   M.S., Sungkyunkwan University, Korea (2012)
   B.S., Sungkyunkwan University, Korea (2010)

 
Research  
 

 (1) Structural biochemistry on pathogenic viruses (Corona- or influenza- viruses)

We are aiming to understand the causes and the effects of pathogenic viruses at the molecular level. Currently, proteins from coronaviruses (e.g. SARS-CoV-2; COVID-19 virus) are being studied by structural- and biochemical- methods.

 

 (2) Understanding host-pathogen protein-protein interactions from pathogenic bacteria

We also try to understand the interactions happening between proteins from the host and pathogenic bacteria such as Streptococcus, Legionella, Mycobacterium, Salmonella, etc.

 

 (3) Ubiquitin system from pathogens (bacteria or viruses)

Even though prokaryotes do not have ubiquitin in their genome, there are several proteins that alter or utilize host ubiquitin machinery. We are trying to understand the structure and molecular basis of ubiquitin-mediated interactions between hosts and pathogens.

 
 
Publications  
 

최근 3년, 2020~2022

- 2022
J. Jung, J. Baek, K. Tae, D. Shin, S. Han, W. Yang, W. Yu, S. Jung, S-H. Park, C. Y. Choi, S. Lee. Structural mechanism for regulation of Rab7 by site-specific monoubiquitination. Int. J. Biol. Macromol. 194, 347-357 (2022)

- 2021
R. Mukherjee, A. Bhattacharya, D. Bojkova, A.R. Mehdipour, D. Shin, K. S. Khan, H. H-Y. Cheung, K-B, Wong, W-L. Ng, J. Cinnatl, P. Geurink, G. J. Noort, K. Rajalingam, S. Ciesek, G. Hummer , I. Dikic. Famotidine inhibits Toll-like receptor 3-mediated inflammatory signaling in SARS-CoV2 infection. J. Biol. Chem. 297(2), 100925 (2021)

H. S. Lo, K. P. Y. Hui, H-M. Lai, X. He, K. S. Khan, S. Kaur, J. Huang, Z. Li, A. K. N. Chan, H. H-Y. Cheung, K-C. Ng, J. C. W. Ho, Y. W. Chen, B. Ma, P. M-H. Cheung, D. Shin, K. Wang, M-H. Lee, B. Selisko, C. Eydoux, J-C. Guillemot, B. Canard, K-P. Wu, P-H. Liang, I. Dikic, Z. Zuo, F. K. L. Chan, D. S. C. Hui, V. C. T. Mok, K-B. Wong, C. K. P. Mok, H. Ko, W. S. Aik, M. C. W. Chan, W-L Ng. Simprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir. ACS Central Sci.. 7(5), 792-802 (2021)

D. W. Choi, Y. J. Roh, S. Kim, H. M. Lee, M. Kim, D. Shin, J. H. Park, Y. Cho, H. H. Park, Y. S. Oh, D. Kang, J-H. Kim, L. Tarrago, N. N. Danial, V. N. Gladyshev, P-K. Min, B. C. Lee. Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues. Biosens. Bioelectron. 178, 113031 (2021)

- 2020
D. Shin, R. Mukherjee, D. Grewe, D. Bojkova, K. Baek, A. Bhattacharya, L. Schulz, M. Widera, A. R.Mehdipour, G. Tascher, P. P. Geurink, A. Wilhelm, G. J. Noort, H. Ovaa, S. Muller, K.Knobeloch, K. Rajalingam, B. A. Schulman, J. Cinatl, G. Hummer, S. Ciesek, I. Dikic. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. 587, 657-662 (2020)

D. Shin, A. Bhattacharya, Y. Cheng, M. C. Alonso, A. R. Medipour, G. J. Noort, H. Ovaa, G. Hummer, I. Dikic. Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. eLife. 2020(9);e58277, (2020)

R. Q. Kim, M. Misra, A. Gonzalez, I. Tomaskovic, D. Shin, H. Schindelin, D. V. Filippov, I. Dikic, H. Ovaa, G. J. Noort. Development of ADPribosyl ubiquitin analogues to study enzymes involved in Legionella infection. Chem. Eur. J. 27, 2506-2512 (2020)

D. Shin*, R. Mukherjee*, Y. Liu*, A. Gonzalez, F. Bonn, Y. Liu, V. V. Rogov, M. Heinz, A. Stolz, G. Hummer, V. Dotsch, Zhao-Qing Luo, Sagar Bhogaraju, Ivan Dikic. Regulation of phosphoribosyl-linked serine ubiquitination by deubiquitinases DupA and DupB. Mol. Cell. 77(1), 164-179 (2020) *Equal contribution

J. Kim, H. Lee, Y. J. Roh, H. Kim, D. Shin, S. Kim, J. Son, A. Lee, M. Kim, J. Park, S. Y. Hwang, K. Kim, Y. K. Lee, H. S. Jung, K. Y. Hwang, B. C. Lee. Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3. IUCrJ. 7, ( 2020)

 
     
 
멤버사진
확대보기  

 지도교수: 신동혁 교수

   (2022년 현재)
 Graduate Students : 정민우, 최민형, 강상우, 전하영
 Undergraduates : 이소은
 Contact :
donghyuk.shin@yonsei.ac.kr , Lab: 02-2123-7583
 Homepage: https://sites.google.com/view/donghyuk-shin/home

 
     
* 본 정보는 해당 대학/연구실에서 제공하는 자료를 바탕으로 구성된 내용으로, BRIC에서 작성한 정보가 아님을 밝힙니다.
* 소개된 내용에서 중요하게 판단되는 부분은 해당 기관에 추가적으로 사실 확인 작업을 하시길 부탁드립니다.
* 내용의 업데이트 또는 변경을 원하시면 관리자(news@ibric.org)에게 연락 바랍니다.
등록일 2022.11.28
주소복사
HOME   |   이용약관   |   개인정보처리방침
© BRIC