BioLab
BioWave,  Vol. 25 No. 3
세종대학교 생명시스템학부 식품생명공학과 Food Metabolism&Toxicology lab 심순미 교수
연구실 홈페이지
Introduction  
 

 Our goals are to build up the scientific database on health benefits of natural resources which have been consumed by ancestors and to provide commercial products to let people be “young and healthy to inner- and outer- well-being” through the modern cutting-edge technologies. To achieve these goals, our group mainly do the following tasks - profiling of multi-bioactive components in natural resources, development of efficacy-maximizing technologies through increasing bioavailability, lab & pilot-scaled product development, and contents planning for effective marketing based on products’ scientific data.

 In addition, to foster disciples in food industries needed for the Fourth Industrial Revolution, we run connected projects with undergraduate students, which they can experience from the very beginning of the product development to product marketing.

 

  Soon-Mi Shim (Ph.D)
  Professor of Food Metabolism and Toxicology & Special appointed professor, Shnshu university

   2011: Professor, Dept. of Food Science and Technology, Sejong University
   2009~2010: Research Professor, Dept. of Food Science and Technology, Ewha Womans University
   2006~2008: Post-doctoral associate, Dept. of Food and Nutrition, Seoul National University
   2001~2005: Ph.D. Dept. of Food Science, Purdue University
   1998-2000: Ms.D. Dept. of Food and Nutrition, Duksung Women’s University
   1992-1997: Bs.D. Dept. of Food and Nutrition, Duksung Women’s University

 
 
Research  
 

 1. Research intersts
  - 식품 및 향장 식품소재의 소화, 흡수 및 대사 기작 규명을 통한 생체이용률 규명
  Elucidation of bioavailability by evaluating digestion, absorption, metabolism of Food ingredients and cosmetic ingredients

  - 기능성 성분 원료표준화 및 다양한 기능성 평가를 통한 건강 기능성 증진 소재 탐색 및 개발
  Standardization of functional ingredients and evaulation of various functionality for developing functional foods

  - 식물의 이차대사산물을 이용한 화학적 독성 제어
  Control of food toxicology induced by chemical hazards by using phytochemicals

  - 빅테이타 기술기반 위해요소관리 및 위생안전 향상 기술개발
  Development of food safety and control of food hazards based on big data techinque

 2. Research keywords
  Plant secondary metabolites (phytochemicals)
  Gut absorption and metabolism
  Biomimick system
  Colon metabolites
  Pharmacokinetics
  Detox
 
Publications  
 

최근 3년, 2019~2021

 - 2021

1) Nam, S., Lee, C. Y., Shim, S. M., Lee, D. U., & Lee, S. (2021). Functional Characterization of Marigold Powder as a Food Ingredient for Lutein-Fortified Fresh Noodles. Applied Sciences, 11(2), 861.

2) Lee, C. Y., Oh, J. H., Chung, J. O., Rha, C. S., Park, M. Y., Hong, Y. D., ... & Shim, S. M. (2021). Effect of whole green tea products including catechins, polysaccharides, and flavonols on the metabolism of added sugars. Food Bioscience, 41, 100936.

3) Oh, J. H., Lee, C. Y., Lee, Y. E., Yoo, S. H., Chung, J. O., Rha, C. S., ... & Shim, S. M. (2021). Profiling of In Vitro Bioaccessibility and Intestinal Uptake of Flavonoids after Consumption of Commonly Available Green Tea Types. Molecules, 26(6), 1518.

4) Lee, D. Y., Chun, Y. S., Kim, J. K., Lee, J. O., Lee, Y. J., Ku, S. K., & Shim, S. M. (2021). Curcumin Ameliorated Oxidative Stress and Inflammation-Related Muscle Disorders in C2C12 Myoblast Cells. Antioxidants, 10(3), 476.

5) Lee, D. Y., Chun, Y. S., Kim, J. K., Lee, J. O., Ku, S. K., & Shim, S. M. (2021). Curcumin Attenuates Sarcopenia in Chronic Forced Exercise Executed Aged Mice by Regulating Muscle Degradation and Protein Synthesis with Antioxidant and Anti-inflammatory Effects. Journal of Agricultural and Food Chemistry, 69(22), 6214-6228.

6) Oh, J. H., Chung, J. O., Lee, C. Y., Yun, Y., Park, M. Y., Hong, Y. D., Kim, W. G., Cha, H. Y., Shin, K. S., Hong, G. P., Shim, S. M. (2021). Characterized Polysaccharides from Green Tea Inhibited Starch Hydrolysis and Glucose Intestinal Uptake by Inducing Microstructural Changes of Wheat Starch. Journal of Agricultural and Food Chemistry, 69(47), 14075-14085.

7) Oh, J. H., Lee, C. Y., Kim, J. E., Kim, W. H., Seo, J. W., Lim, T. G., Lee, S. Y., Chung, J. O., Hong, Y. D., Kim, W. G., Yoo, S. J., Shin, K. S., Shim, S. M. (2021). Effect of Characterized Green Tea Extraction Methods and Formulations on Enzymatic Starch Hydrolysis and Intestinal Glucose Transport. Journal of Agricultural and Food Chemistry, 69(50), 15208-15217.

8) Lee, Y. E., Yoo, S. H., Chung, J. O., Rha, C. S., Park, M. Y., Lee, H. J., Oh, J. H., Hong, Y. D., Shim, S. M. (2021). Impact of flavonol extracts derived from green tea or targeted flavonols as secondary ingredients on intestinal glucose transport. Journal of Food Science and Technology, 1-9

9) Kim, J. H., Kim, J. E., Kim, W. H., Tan, K. V., Shim, S. M. (2021). Plant based protein products: Characterization and functionality of dried tofu noodles containing lotus root powder. Food Bioscience, 43, 101342.

10) Lee, D. Y., Lee, C. Y., Shin, J. N., Oh, J. H., Shim, S. M. (2021). Impact of soy lecithin, zinc oxide, and methylsulfonylmethane, as excipient ingredients, on the bioaccessibility and intestinal transport of branched-chain amino acids from animal and plant protein mixtures. Food Function, 12, 11399-11407.

 - 2020

1) Lee, D. Y., Oh, J. H., Uhm, J. T., Kim, I. H., Park, M. J., Moon, S. H., ... & Shim, S. M. (2020). Impact of acidity regulator and excipient nutrients on digestive solubility and intestinal transport of calcium from calcium phosphate and carbonate. Food & Function, 11(12), 10655-10664.

2) Choi, E. H., Chun, Y. S., Kim, J., Ku, S. K., Jeon, S., Park, T. S., & Shim, S. M. (2020). Modulating lipid and glucose metabolism by glycosylated kaempferol rich roasted leaves of Lycium chinense via upregulating adiponectin and AMPK activation in obese mice-induced type 2 diabetes. Journal of Functional Foods, 72, 104072.

3) Yoo, S. H., Lee, Y. E., Chung, J. O., Rha, C. S., Hong, Y. D., Park, M. Y., & Shim, S. M. (2020). Addition of flavonols and polysaccharides as excipient ingredients into epicatechin rich green tea extract inhibited free radical formation and glucose uptake. Food & function, 11(4), 3105-3111.

4) Lee, H. J., Shin, C., Chun, Y. S., Kim, J., Jung, H., Choung, J., & Shim, S. M. (2020). Physicochemical properties and bioavailability of naturally formulated fat?soluble vitamins extracted from agricultural products for complementary use for natural vitamin supplements. Food Science & Nutrition, 8(10), 5660-5672.

5) Lee, H. J., Lim, J., Peak, J., Ki, M. S., Lee, S. B., Choe, G., ... & Shim, S. M. (2020). Effect of Melissa officinalis L. leaf extract on lipid accumulation by modulating specific adipogenic gene transcription factors in 3T3-L1 adipocytes. Journal of Applied Biological Chemistry, 63(2), 169-174.

6) Jeon, S., Song, J., Lee, D., Kim, G. T., Park, S. H., Shin, D. Y., ... & Park, T. S. (2020). Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice. Journal of lipid research, 61(1), 20-32.

7) Yoo, S. H., Lee, Y. E., Chung, J. O., Rha, C. S., Hong, Y. D., Park, M. Y., & Shim, S. M. (2020). Enhancing the effect of catechins with green tea flavonol and polysaccharides on preventing lipid absorption and accumulation. LWT, 134, 110032.

8) Lee, Y. E., Yoo, S. H., Chung, J. O., Park, M. Y., Hong, Y. D., Park, S. H., ... & Shim, S. M. (2020). Hypoglycemic effect of soluble polysaccharide and catechins from green tea on inhibiting intestinal transport of glucose. Journal of the Science of Food and Agriculture, 100(10), 3979-3986.

 - 2019

1) Chung, J. O., Yoo, S. H., Lee, Y. E., Shin, K. S., Yoo, S. J., Park, S. H., ... & Shim, S. M. (2019). Hypoglycemic potential of whole green tea: water-soluble green tea polysaccharides combined with green tea extract delays digestibility and intestinal glucose transport of rice starch. Food & function, 10(2), 746-753.

2) Choi, E. H., Rha, C. S., Balusamy, S. R., Kim, D. O., & Shim, S. M. (2019). Impact of bioconversion of gallated catechins and flavonol glycosides on bioaccessibility and intestinal cellular uptake of catechins. Journal of agricultural and food chemistry, 67(8), 2331-2339.

3) Choi, E. H., Lee, D. Y., Park, H. S., & Shim, S. M. (2019). Changes in the profiling of bioactive components with the roasting process in Lycium chinense leaves and the anti?obesity effect of its bioaccessible fractions. Journal of the Science of Food and Agriculture, 99(9), 4482-4492.

4) Song, Y. J., Kim, A., Kim, G. T., Yu, H. Y., Lee, E. S., Park, M. J., ... & Park, T. S. (2019). Inhibition of lactate dehydrogenase A suppresses inflammatory response in RAW 264.7 macrophages. Molecular medicine reports, 19(1), 629-637.

5) Jeong, K. H., Lee, H. J., Park, T. S., & Shim, S. M. (2019). Catechins Controlled Bioavailability of Benzo [a] pyrene (B [α] P) from the Gastrointestinal Tract to the Brain towards Reducing Brain Toxicity Using the In Vitro Bio-Mimic System Coupled with Sequential Co-Cultures. Molecules, 24(11), 2175.

6) Tran, N. K. S., Kim, G. T., Park, S. H., Lee, D., Shim, S. M., & Park, T. S. (2019). Fermented Cordyceps militaris extract prevents hepatosteatosis and adipocyte hypertrophy in high fat diet-fed mice. Nutrients, 11(5), 1015.

 
 
     
 
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 지도교수: 심순미 교수

   (2022년 현재)
 Master's course : 최원조, 이준서, 김우현, 김정은, Vu tan Kiet
 상임연구원(Researcher) : 조소연
 Contact : soonmishim@sejong.ac.kr , Lab: 82-2-467-2017
 Homepage: http://www.fometlab.com/
 
     
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