BioWave,  Vol. 24 No. 12
영남대학교 약학대학 신경생화학연구실 김수영 교수
연구실 홈페이지
Introduction  
 

 영남대학교 약학대학 신경생화학 연구실에서는 발달성 (자폐증, 조현병 등) 및 퇴행성 (알츠하이머 등) 뇌질환 에서 발견되는 시냅스 미세환경의 병리적 변화를 규명하고 주요 진단 마커의 발굴을 위하여 생화학, 세포생물학, 신경생물학, 행동신경학 및 생물정보학 등의 다양한 접근을 통한 연구를 진행하고 있습니다. 시냅스 병리의 원인으로 신경세포 주위의 다양한 세포들 - 뉴런, 성상세포, 혈관세포 등 사이의 상호 작용에 초점을 맞추어 자폐증 병리 기전, 뇌내 종양 미세환경 연구 및 치매관련 유전자 위험요인 연구를 진행 중입니다.

 Dr. Soo Young Kim completed her B.Sc in Pharmacy and M.Sc in Bioinformatics/Biochemistry at Seoul National University. She completed her Ph.D in Neuroscience with Dr. Theresa A. Jones at University of Texas at Austin, where she elucidated how interactions between neurons and astrocytes shape synaptic plasticity after brain damage. In her postdoctoral training with Dr. Daniela Kaufer at University of California Berkeley, her research was focused on how changes in glia and other components in synaptic microenvironments play a role in the pathology of deficits in inhibitory neurons. With her continued research interest in progressive brain disorders, she investigated aberrant synaptic plasticity using genetic models of autism and schizophrenia while holding a position as a Research Fellow at the Institute for Basic Science (IBS). She is currently an assistant professor in the Department of Pharmacy at Yeungnam University and an adjunct research fellow in IBS.

 
Research  
 

- Research projects in NBCL are focused on cell-cell interactions in neurovascular units and their link to brain disorders.

 
Publications  
 

Yoo T*, Joshi S*, Prajapati S, Cho YS, Kim J, Park P-H, Bae YC, Kim E, Kim SY†. 2022. A deficiency of the psychiatric risk gene DLG2/PSD-93 causes excitatory synaptic deficits in the dorsolateral striatum. Frontiers in Molecular Neuroscience. In Press.

Uprety A*, Kang Y*, Kim SY†. 2021. Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders. Arch Pharm Res. ePub Ahead.

Yoo T, Kim SG, Yang SH, Kim H, Kim E, Kim SY† 2020. A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum. Molecular Autism. 11(1):19.

Yook C., Kim K, Kim D, Kang H, Kim SG, Kim E†*, Kim SY†* 2019. A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice. Frontiers in Molecular Neuroscience. 12:241.

Kim SY†*, Hsu JE*, Husbands LC, Kleim JA, Jones TA. 2018. Coordinated plasticity of synapses and astrocytes underlies practice-driven functional vicariation in peri-infarct motor cortex. Journal of Neuroscience. 38(1) 93-107.

Kim SY†*, Senatorov VV Jr., Morrissey CS, Lippmann K, Vasquez O, Milkovsky DZ, Gu F, Prada I, Prince D, Becker AJ, Heinemann U, Friedman A, Kaufer D†*. 2017. TGFb signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. Scientific Reports. 7:7711.

Lippmann K, Kamintsky L, Kim SY, Lublinsky S, Prager O, Nichtweib JF, Salar S, Kaufer D, Heinemann U, Friedman A. 2017. Epileptiform activity and spreading depolarization in the blood-brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition and synaptic plasticity. Journal of Cerebral Blood Flow and Metabolism. 37(5):1803-1819.

Kim SY, Porter BE, Friedman A, Kaufer, D. 2016. A potential role for glia-derived extracellular matrix remodeling in post-injury epilepsy. Journal of Neuroscience Research. 94(9):794-803.

Kim SY†, Allred RP, Adkins DL, Tennant KA, Donlan NA, Kleim JA, Jones TA. 2015. Experience with the “good” limb induces aberrant synaptic plasticity in the perilesion cortex after stroke. Journal of Neuroscience. 35(22):8604-10.

Allred RP, Kim SY, Jones TA. 2014. Use it and/or lose it--experience effects on brain remodeling across time after stroke. Frontiers in Human Neuroscience 8:379.

Bar-Klein G, Cacheaux LP, Kamintsky L, Prager O, Weissberg I, Schoknecht K, Cheng PJ, Kim SY, Wood L, Heinemann U, Kaufer D, Friedman A. 2014. Losartan prevents acquired epilepsy via TGF-b signaling suppression. Annals of Neurology. 75(6):864-75.

Kim SY†, Jones TA. 2013. The effects of ceftriaxone on skill learning and motor functional outcome after ischemic cortical damage in rats. Restorative Neurology and Neuroscience 31(1):87-97.

Kim SY, Buckwalter M, Soreq H, Vezzani A, Kaufer D. 2012. Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia 53(s6): 37-44.

Kim SY, Jones TA. 2010. Lesion size-dependent synaptic and astrocytic responses to cortical infarcts in middle aged rats. Synapse 64(9):659-71.

Bae MK, Jeong JW, Kim SH, Kim SY, Kang HJ, Kim DM, Bae SK, Yun I, Trentin GA, Rozakis-Adcock M, Kim KW. 2005. Tid-1 interacts with pVHL and modulates angiogenesis by destabilization of HIF-1. Cancer Research 65(7):2520-5.

Kim SY, Lee SW, You SY, Rha SY, Kim KW. 2004. In silico screening for angiogenesis-related genes in rat astrocytes. Genomics & Informatics 2(1):39-47.

Park JA, Choi KS, Kim SY, Kim KW. 2003. Coordinated interaction of the vascular and nervous systems: from molecule- to cell-based approaches. Biochem Biophys Res Commun. 311(2):247-53.

†corresponding author, *equally contributed

 

 
     
 
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 지도교수: 김수영 교수

   (2022년 현재)
 PhD Program: Shambhu Joshi
 MS-PhD Integrative Program: Ajay Uprety
 MS Program: Sanjaya Prajapati, Ngoc Nguyen Huyen
 Undergrad Research Associates: 최연지, 박기욱, 구민성, 박재문, 이재현, 정홍찬
 Contact :
sooykim@yu.ac.kr
 Homepage: https://sites.google.com/yu.ac.kr/nbcl/nbcl

 
     
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