BioWave,  Vol. 24 No. 11
성균관대학교 글로벌바이오메디컬공학과 Nature-inspired Biomaterials Engineering Lab 신미경 교수
연구실 홈페이지
실험실 소개  
 

 Our main research scope is to design nature-inspired adhesive materials via catechol or gallol redox chemistry. We have focused on developing a variety of adhesive biomedical formulations exhibiting hemostatic effect, minimally invasive, hemostatic medical devices as well as adhesion/affinity-based drug-delivery carriers based on mussel-inspired catechol/its derivatives chemistry for wet-resistant adhesion. The ultimate goal of our research is to design a new generation of biomaterial-based practical medical tools capable of diagnosing and treating actual patients.

 
연구 분야  
 

■ Research Highlight

Optically anisotropic topical hemostatic agents containing plant polyphenols (Adv. Funct. Mater. 2021)

For prevention of internal rehemorrhage in limited clinical settings, it is important to develop effective topical hemostatic formulations and monitor their hemostatic process without optical labeling. Thus, we developed optically anisotropic liquid crystal/plant polyphenol-based hemostatic coacervate for clear identification of blood coagulation process. Spontaneous generation of “polyphenol-blood physical barrier” on the tissue followed by green colored visualization of liquid crystal apparently showed termination of blood coagulation.

Molecular Rationale for the Design of Instantaneous, Strain-Tolerant Polymeric Adhesive in a Stretchable Underwater Human-Machine Interface (ACS Nano 2022)

In this study, we report an instantaneous polymeric adhesive with high strain tolerance (termed as iPASTE) even in a stretchable human?machine interface. The iPASTE consists of two biocompatible and eco-friendly polymers, linearly oligomerized green tea extracts, and poly(ethylene glycol) for densely assembled networks via dynamic and reversible hydrogen bonds. Based on the strain-tolerant adhesion of iPASTE, a subaqueous interactive human?machine interface integrated with a robot arm and a gold nanomembrane strain-sensitive electronic skin can precisely capture a slithery artificial fish by using finger gesture recognition.

 

■ Medical glue

Hemostatic agents/medical devices (Nat. Mater. 2017, Adv. Funct. Mater. 2015)

Tissue-adhesive biomaterials have been attracted for hemostatic agents, wound closure, and other applications to multifunctional medical devices. In particular, we have developed hemostatic polymeric biomaterials for surface coating of medical tools/devices and controlling external/internal bleeding on surgical procedures. Our research scope is highly effective to solve challenging issues of delayed hemostasis from patients with chronic diseases, such as diabetes, advanced cancer, or hemophilia, patients taking aspirin and undergoing chemotherapy/cerebral surgery, and rare case patients with Ebola virus infection.

■ Local drug delivery system

Local drug delivery for cardiovascular applications (Nat. Biomed. Eng. 2018)

A heart is an important organ of cardiovascular system to circulate blood through the whole body. Due to dynamic mechanical motions and large cardiac output, targeting drugs to the heart is inevitably challenging. Although cardiovascular diseases, such as myocardial infarction, valvular and coronary artery diseases, seriously affect the world population, direct treatment of those diseases is performed by surgical procedures such as a sternotomy or thoracotomy, which unavoidably involve incision of the chest wall. Thus, we have developed local drug/protein delivery platform to target the heart via systemic/intramyocardial injections on a basis of intermolecular affinity of catechol/gallol moieties to biomacromolecules against shear stress in vivo.

■ 3D printable inks

3D printable inks and tissue fabrication (Acta Biomater. 2018, Adv. Sci. 2019)

We are interested in developing advanced 3D printable hydrogel inks with unique physicochemical properties. In 3D printing techniques, polyphenol chemistry provides an insight for designing tissue-adhesive and mechanically tough ink materials. In addition to that, we have focused on exploring conductive and injectable materials for further printing of wearable/flexible, electroactive pattern.

 
연구 성과  
 

- Papers(2019~현재)

1. “Molecular Rationale for the Design of Instantaneous, Strain-Tolerant Polymeric Adhesive in a Stretchable Underwater Human-Machine Interface”, ACS Nano 2022, 16, 1368-1380
Yeonsun Choi, Kyumin Kang, Donghee Son*, and Mikyung Shin*


2. “Polyphenol-Modified Nanovesicles for Synergistically Enhanced in vitro Tumor Cell Targeting and Apoptosis”, Journal of Materials Chemistry B 2022, Accepted
Yeonsun Choi, Kyumin Kang, Donghee Son*, and Mikyung Shin*


3. “Lead-Sealed Stretchable Underwater Perovskite-Based Optoelectronics via Self-Recovering Polymeric Nanomaterials”, ACS Nano 2021, In press
Jinhyun Kim , Duhwan Seong, Hannah Kwon, Subin Jin, Hyejun Kim, Yewon Kim, Yongcheol Jeong, Kwanil Lee, Seok Joon Kwon, Mikyung Shin, Donghee Son*, and In Soo Kim*


4. “Optically Anisotropic Topical Hemostatic Coacervate for Naked-Eye Identification of Blood Coagulation”, Adv. Funct. Mater. 2021, 2110320
Subin Jin, Sumin Kim, Dae Seok Kim, Donghee Son, Mikyung Shin*


5. “Antigen-Antibody Interaction-Derived Bioadhesion of Bacterial Cellulose Nanofibers to Promote Topical Wound Healing”, Adv. Funct. Mater. 2022, In press
Seulgi Kim, Jina Ko, Jae Hyuk Choi, Jeong Yi Kang, Chanoong Lim, Mikyung Shin*, Dong Woog Lee *, Jin Woong Kim*


6. “Sundew-Inspired Adhesive Hydrogel Threads through Reversible Complexation of Polyphenol and Boronic Acid”, Appl. Sci. 2021, 11, 8591
Jae Hyuk Choi, Donghee Son*, Mikyung Shin*


7. “Skin-like Transparent Polymer-Hydrogel Hybrid Pressure Sensor with Pyramid Microstructures”, Polymers 2021, 13, 3272
Kyumin Kang, Hyunjin Jung, Soojung An, Hyoung Won Baac, Mikyung Shin*, Donghee Son*


8. “Role of Free Catecholamine in Thiol-Ene Crosslinking for Hyaluronic Acid Hydrogels with High Loading Efficiency of Anticancer Drugs”, Tissue Engineering and Regenerative Medicine 2021, 1-7
Sumin Kim, Mikyung Shin*


9. “Phenol-Hyaluronic Acid Conjugates: Correlation of Oxidative Crosslinking Pathway and Adhesiveness”, Polymers 2021, 13, 3130
Jungwoo Kim, Sumin Kim, Donghee Son*, and Mikyung Shin*


10. “A Soft Pressure Sensor Array Based on a Conducting Nanomembrane”, Micromachines 2021, 12, 933
Daekwang Jung, Kyumin Kang, Hyunjin Jung, Duhwan Seong, Soojung An, Jiyong Yoon, Wooseok Kim, Mikyung Shin, Hyoung Won Baac, Sangmin Won, Changhwan Shin*, Donghee Son*


11. “Mechanically and electrically durable, stretchable electronic textiles for robust wearable electronics”, RSC Adv. 2021, 11, 22327-22333
Sun Hong Kim, Yewon Kim, Heewon Choi, Juhyung Park, Jeong Han Song, Hyoung Won Baac, Mikyung Shin, Jeonghun Kwak* and Donghee Son*


12. “Fabrication of cell penetrating peptide-conjugated bacterial cellulose nanofibrils with remarkable skin adhesion and water retention performance”, Int. J. Pharm 2021, 600, 120476
Seulgi Kim, Jeong Yi Kang, William C.Balance, Bradley P.Sutton, Dae HyunShin, Kyoung Hee Jang, Mikyung Shin, Hyunjoon Kong, Jin Woong Kim*


13. “Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling”, Adv. Mater 2021, 20, 2007346
Hyunseon Seo, Sang Ihn Han, Kang-Il Song, Duhwan Seong, Kyungwoo Lee, Sun Hong Kim, Taesung Park, Ja Hoon Koo, Mikyung Shin, Hyoung Won Baac, Ok Kyu Park, Soong Ju Oh, Hyung-Seop Han, Hojeong Jeon, Yu-Chan Kim, Dae-Hyeong Kim,* Taeghwan Hyeon,* and Donghee Son*


14. “Designing Adaptive Binders for Microenvironment Settings of Silicon Anode Particles”, Adv. Mater 2021, 13, 2007460
Haesung A. Lee, Mikyung Shin, Jaemin Kim, Jang Wook Choi*, Haeshin Lee*


15. “Hemostatic Needles: Controlling Hemostasis Time by a Catecholamine Oxidative Pathway”, ACS Appl. Mater. Interfaces 2021, 13, 9, 10741-10747
Mikyung Shin, Jae Hyuk Choi, Keumyeon Kim, Soomi Kim, and Haeshin Lee*


16. “Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics”, Polymers 2021, 13, 1133
Yeonsun Choi, Kyuha Park, Heewon Choi, Donghee Son*, and Mikyung Shin*


17. “Mechanical Stabilization of Alginate Hydrogel Fiber and 3D Constructs by Mussel-Inspired Catechol Modification”, Polymers 2021, 13, 892
Kyoungryong Kim, Jae Hyuk Choi, Mikyung Shin


18. “Diatom frustule silica exhibits superhydrophilicity and superhemophilicity”, ACS Nano 2020, 14, 4, 4755?4766
Jeehee Lee, Haesung A. Lee, Mikyung Shin, Lih Jiin Juang, Christian J. Kastrup, Gyung Min Go*, and Haeshin Lee*


19. “Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support”, Adv. Sci 2019, 20, 1901229
Mikyung Shin, Kwang Hoon Song, Justin C. Burrell, D. Kacy Cullen, Jason A. Burdick*


20. “Plant-Inspired Pyrogallol-Containing Functional Materials”, Adv. Funct. Mater. 2019, 29, 1903022
Mikyung Shin, Eunsook Park, and Haeshin Lee*


21. “Gallol-derived ECM-mimetic adhesive bioinks exhibiting temporal shear-thinning and stabilization behavior”, Acta Biomaterialia 2019, 95, 165
Mikyung Shin, Jonathan H. Galarraga, Mi Y. Kwon, Haeshin Lee, Jason A.Burdick*


22. “Safety and efficacy evaluations of an adeno-associated virus variant for preparing IL10-secreting human neural stem cell-based therapeutics”, Gene Ther 2019, 26, 135
Mira Cho, Kwangsoo Jung, Seung-Hyun Kim, Il-Sun Kim, Miri Kim, Mikyung Shin, Haeshin Lee, Kook In Park*, Jae-Hyung Jang*


23. “Alginate-Boronic Acid: pH-Triggered Bioinspired Glue for Hydrogel Assembly”, Adv. Funct. Mater. 2020, 30, 1908497
Sang Hyeon Hong, Mikyung Shin, Eunsook Park, Ji Hyun Ryu, Jason A. Burdick, and Haeshin Lee*


24. “Surface Modification and Medical Formulation Technology Using Adhesion of Plant Tannic Acid”, Journal of Adhesion and Interface, 2019, 20, 71
Eunsook Park, Mikyung Shin, and Haeshin Lee*

 

- BOOK

1. “Chapter 9: Catechology: The Study of Mussel- and Insect-inspired Adhesion, Coating, and Chemoselective Reaction”, Soft Matter and Biomaterials on the Nanoscale, World Scientific Series in Nanoscience and Nanotechnology 2020, Pages 261-288
Sang Hyeon Hong, In Taek Song, Eunsook Park, Mikyung Shin, Haeshin Lee


2. “Biological applications of adhesive biomolecules inspired by nature”, Korean Molecular and Cellular Biology Newsletter, 2017, September, 1-6.
I. T. Song, M. Lee, Mikyung Shin, K. Lee, Haeshin Lee


3.“Chapter 15. Stimuli-responsive Mussel-inspired polydopamine material, Stimuli-Responsive Dewetting/Wetting Smart Surfaces and Interfaces”, Springer 2018. Pages 437-454
Mikyung Shin, Y. Wang, Haeshin Lee

 

- International patents

1. “Agent for targeting heart comprising tannic acid”
Mikyung Shin, Hyang-Ae Lee, Sun Hyun Park, Ki-Suk Kim, Haeshin Lee


2. “Hemostatic injection needle coated with crosslinked chitosan having catechol group and oxidized catechol group”
Haeshin Lee, Mikyung Shin, Moon Sue Lee, Seok Song Oh

 
     
 
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 지도교수: 신미경 교수

 M.S/Ph.D candidate: Subin Jin, Sumin Kim, Jungwoo Kim, Kyoungryong Kim, Jaewon Ju
 M.S. candidate: Yeonsun Choi, Sung Dong Kim
 Contact :
mikyungshin@g.skku.edu, Lab:+82-31-299-4344
 Homepage: https://nbel.skku.edu/

 
     
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